Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat

The antidepressant drug tianeptine increased rat plasma 5-hydroxyindoleacetic (5-HIAA) concentrations after single and repeated treatment for 14 days. This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and...

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Veröffentlicht in:	European journal of pharmacology 1991-07, Vol.199 (3), p.335-339
Hauptverfasser:	Ortiz, Jordi, Mocaër, Elisabeth, Artigas, Francesc
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT synthesis 5-HT uptake Animals Antidepressants Antidepressive Agents, Tricyclic - pharmacology Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Brain - drug effects Brain - metabolism Hydroxyindoleacetic Acid - blood Male Medical sciences Neuropharmacology Neurotransmitter Uptake Inhibitors - pharmacology Pharmacology. Drug treatments Plasma Platelets Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Serotonin - biosynthesis Serotonin - blood Thiazepines - pharmacology Tianeptine Time Factors
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