Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat
The antidepressant drug tianeptine increased rat plasma 5-hydroxyindoleacetic (5-HIAA) concentrations after single and repeated treatment for 14 days. This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and...
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| Veröffentlicht in: | European journal of pharmacology 1991-07, Vol.199 (3), p.335-339 |
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| creator | Ortiz, Jordi Mocaër, Elisabeth Artigas, Francesc |
| description | The antidepressant drug tianeptine increased rat plasma 5-hydroxyindoleacetic (5-HIAA) concentrations after single and repeated treatment for 14 days. This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and brain. A concurrent decrease in platelet-free plasma 5-HT concentrations occurred after subchronic treatment. Tianeptine attenuated the large increase in 5-HT concentrations in platelet-free plasma elicited by the specific 5-HT uptake inhibitors citalopram and paroxetine. These data are compatible with the reported 5-HT uptake-enhancing activity of this antidepressant drug. |
| doi_str_mv | 10.1016/0014-2999(91)90497-E |
| format | Article |
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This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and brain. A concurrent decrease in platelet-free plasma 5-HT concentrations occurred after subchronic treatment. Tianeptine attenuated the large increase in 5-HT concentrations in platelet-free plasma elicited by the specific 5-HT uptake inhibitors citalopram and paroxetine. 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Psychiatry ; Psychopharmacology ; Rats ; Rats, Inbred Strains ; Serotonin - biosynthesis ; Serotonin - blood ; Thiazepines - pharmacology ; Tianeptine ; Time Factors</subject><ispartof>European journal of pharmacology, 1991-07, Vol.199 (3), p.335-339</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-774b5b7d60cd77484cdd8f965f64594a7a84b980c4dcb79a9b70fcd72bd0282b3</citedby><cites>FETCH-LOGICAL-c418t-774b5b7d60cd77484cdd8f965f64594a7a84b980c4dcb79a9b70fcd72bd0282b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(91)90497-E$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19798411$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1717295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortiz, Jordi</creatorcontrib><creatorcontrib>Mocaër, Elisabeth</creatorcontrib><creatorcontrib>Artigas, Francesc</creatorcontrib><title>Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The antidepressant drug tianeptine increased rat plasma 5-hydroxyindoleacetic (5-HIAA) concentrations after single and repeated treatment for 14 days. This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and brain. A concurrent decrease in platelet-free plasma 5-HT concentrations occurred after subchronic treatment. Tianeptine attenuated the large increase in 5-HT concentrations in platelet-free plasma elicited by the specific 5-HT uptake inhibitors citalopram and paroxetine. These data are compatible with the reported 5-HT uptake-enhancing activity of this antidepressant drug.</description><subject>5-HT synthesis</subject><subject>5-HT uptake</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Antidepressive Agents, Tricyclic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Hydroxyindoleacetic Acid - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitter Uptake Inhibitors - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasma</subject><subject>Platelets</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Serotonin - biosynthesis</subject><subject>Serotonin - blood</subject><subject>Thiazepines - pharmacology</subject><subject>Tianeptine</subject><subject>Time Factors</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-PFCEQxYnRrOPqN9CEi0YPrcDSDXUxMZvxT7KJFz0TGgoX0wMtMCZ-e2ln4t70REH96qV4j5CnnL3mjE9vGONyEADwEvgrYBLUsL9HdlwrGJji4j7Z_UUekke1fmeMjSDGC3LBFVcCxh253YeArlWaA223SG1q0eNasNZeUl-O32iLNuHaYkKaE10XWw-2g34rGy7YaMWSW04xUZeTw9SKbTGnSvvLptqvj8mDYJeKT87nJfn6fv_l-uNw8_nDp-t3N4OTXLdBKTmPs_ITc77XWjrvdYBpDJMcQVpltZxBMye9mxVYmBULHRWzZ0KL-eqSvDjpriX_OGJt5hCrw2Xpf8jHapTgQkoN_wX5NLErxjdQnkBXcq0Fg1lLPNjyy3BmtiTMZrPZbDbAzZ8kzL6PPTvrH-cD-ruhk_W9__zct9XZJRSbXKx3GCjQkvPOvT1x2F37GbGY6iJ2l30sPTnjc_z3Ir8ByWumXQ</recordid><startdate>19910709</startdate><enddate>19910709</enddate><creator>Ortiz, Jordi</creator><creator>Mocaër, Elisabeth</creator><creator>Artigas, Francesc</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910709</creationdate><title>Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat</title><author>Ortiz, Jordi ; Mocaër, Elisabeth ; Artigas, Francesc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-774b5b7d60cd77484cdd8f965f64594a7a84b980c4dcb79a9b70fcd72bd0282b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>5-HT synthesis</topic><topic>5-HT uptake</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Antidepressive Agents, Tricyclic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Hydroxyindoleacetic Acid - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitter Uptake Inhibitors - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasma</topic><topic>Platelets</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Serotonin - biosynthesis</topic><topic>Serotonin - blood</topic><topic>Thiazepines - pharmacology</topic><topic>Tianeptine</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ortiz, Jordi</creatorcontrib><creatorcontrib>Mocaër, Elisabeth</creatorcontrib><creatorcontrib>Artigas, Francesc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ortiz, Jordi</au><au>Mocaër, Elisabeth</au><au>Artigas, Francesc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1991-07-09</date><risdate>1991</risdate><volume>199</volume><issue>3</issue><spage>335</spage><epage>339</epage><pages>335-339</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The antidepressant drug tianeptine increased rat plasma 5-hydroxyindoleacetic (5-HIAA) concentrations after single and repeated treatment for 14 days. This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and brain. A concurrent decrease in platelet-free plasma 5-HT concentrations occurred after subchronic treatment. Tianeptine attenuated the large increase in 5-HT concentrations in platelet-free plasma elicited by the specific 5-HT uptake inhibitors citalopram and paroxetine. These data are compatible with the reported 5-HT uptake-enhancing activity of this antidepressant drug.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1717295</pmid><doi>10.1016/0014-2999(91)90497-E</doi><tpages>5</tpages></addata></record> |
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| subjects | 5-HT synthesis 5-HT uptake Animals Antidepressants Antidepressive Agents, Tricyclic - pharmacology Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Brain - drug effects Brain - metabolism Hydroxyindoleacetic Acid - blood Male Medical sciences Neuropharmacology Neurotransmitter Uptake Inhibitors - pharmacology Pharmacology. Drug treatments Plasma Platelets Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Serotonin - biosynthesis Serotonin - blood Thiazepines - pharmacology Tianeptine Time Factors |
| title | Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat |
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