Synthesis and Biological Activity of (S)-2-Amino-3-(2, 5-dihydro-5-oxo-4-isoxazolyl)propanoic Acid (TAN-950 A) Derivatives

(S)-2-Amino-3-(2, 5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A (1)) is a novel amino acid antibiotic which shows a high affinity for glutamate receptors of the central nervous system. To improve the affinity for glutamate receptors, the structure-activity relationships of TAN-950 A derivat...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1991/05/25, Vol.39(5), pp.1199-1212
Hauptverfasser:	TAMURA, Norikazu, MATSUSHITA, Yoshihiro, IWAMA, Toshi, HARADA, Setsuo, KISHIMOTO, Shoji, ITOH, Katsumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology asymmetric synthesis Chemistry Exact sciences and technology excitatory amino acid glutamate receptor Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms In Vitro Techniques Isoxazoles - chemical synthesis Isoxazoles - pharmacology isoxazolone isoxazolyl-L-alanine kainate Microbial Sensitivity Tests N-methyl-D-aspartate Organic chemistry Preparations and properties quisqualate Rats receptor binding Receptors, Glutamate Receptors, N-Methyl-D-Aspartate - drug effects Receptors, Neurotransmitter - drug effects Receptors, Neurotransmitter - metabolism TAN-950 A
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