Leptin receptor isoform expression in rat osteoblasts and their functional analysis

The genetic defect in producing the adipose hormone leptin results among others in a drastic increase of bone mass. The current understanding is that under normal circumstances, osteoblast activity is indirectly suppressed by a hypothalamic relay induced by leptin-signalling in the brain. To investi...

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Veröffentlicht in:	FEBS letters 2002-09, Vol.528 (1), p.43-47
Hauptverfasser:	Lee, Yun-Jung, Park, Jung-Hyun, Ju, Sung-Kyu, You, Kwan-Hee, Ko, Jea Seung, Kim, Hyun-Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Cell Line Cells, Cultured DNA-Binding Proteins - metabolism Flow cytometry Leptin Leptin receptor Osteoblasts Osteoblasts - physiology Phosphorylation Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - physiology Rats Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - physiology Receptors, Leptin Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction STAT3 STAT3 Transcription Factor Trans-Activators - metabolism
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