Self‐nonself discrimination and repertoire selection of human T cells differentiated in an HLA‐semiallogeneic environment following bone marrow transplantation for severe combined immunodeficiency

We have analyzed allorecognition, HLA restriction and T cell receptor (TcR) diversity in an HLA‐heterozygous (HLA‐DRw6,7) severe combined immunodeficiency (SCID) patient whose T cell system had been repopulated by HLA‐homozygous (HLA‐DRw6) paternal T cells following T cell‐depleted bone marrow trans...

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Veröffentlicht in:	European journal of immunology 1991-10, Vol.21 (10), p.2479-2487
Hauptverfasser:	Knobloch, Christian, Goldmann, Shraga F., Friedrich, Wilhelm
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Presenting Cells - immunology Autoantigens - immunology Biological and medical sciences Bone Marrow Transplantation - immunology Cell Differentiation Cytotoxicity, Immunologic Fundamental and applied biological sciences. Psychology Fundamental immunology Genetics of the immune response Haplotypes HLA Antigens - immunology Humans Immunity, Cellular Immunobiology Lymphocyte Depletion Receptors, Antigen, T-Cell, alpha-beta - immunology Severe Combined Immunodeficiency - immunology Severe Combined Immunodeficiency - surgery T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology
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