Fibrosing Colonopathy Revealing Cystic Fibrosis In A Neonate Before Any Pancreatic Enzyme Supplementation
ABSTRACT Although its pathogenesis remains still unknown, fibrosing colonopathy (FCP) is considered to be the result of prolonged treatment by high doses of pancreatic enzyme preparations, in a small proportion of patients who present with cystic fibrosis (CF). We present the case of a newborn with...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2002-09, Vol.35 (3), p.356-359 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Serban, Daniela Elena Florescu, Petre Miu, Nicolae |
| description | ABSTRACT
Although its pathogenesis remains still unknown, fibrosing colonopathy (FCP) is considered to be the result of prolonged treatment by high doses of pancreatic enzyme preparations, in a small proportion of patients who present with cystic fibrosis (CF). We present the case of a newborn with meconium ileus (treated by conservative measures), in which, at the age of 3 weeks, the features of intestinal obstruction made necessary the removal of 15 cm of the proximal large intestine. Macroscopical and especially microscopical appearances typical for FCP were found, despite the absence of any enzymatic treatment. These findings raised the suspicion of CF, which was confirmed 4 weeks later at necropsy by the presence of characteristic pancreatic lesions. This case and another similar report in the literature suggest that the mechanism of FCP must be linked with the disease itself, at least in some patients. Thus, for us, FCP is not a “closed subject” and we sustain the importance of continuing studies, which will shed light on its etiopathogenesis. |
| doi_str_mv | 10.1002/j.1536-4801.2002.tb07834.x |
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Although its pathogenesis remains still unknown, fibrosing colonopathy (FCP) is considered to be the result of prolonged treatment by high doses of pancreatic enzyme preparations, in a small proportion of patients who present with cystic fibrosis (CF). We present the case of a newborn with meconium ileus (treated by conservative measures), in which, at the age of 3 weeks, the features of intestinal obstruction made necessary the removal of 15 cm of the proximal large intestine. Macroscopical and especially microscopical appearances typical for FCP were found, despite the absence of any enzymatic treatment. These findings raised the suspicion of CF, which was confirmed 4 weeks later at necropsy by the presence of characteristic pancreatic lesions. This case and another similar report in the literature suggest that the mechanism of FCP must be linked with the disease itself, at least in some patients. Thus, for us, FCP is not a “closed subject” and we sustain the importance of continuing studies, which will shed light on its etiopathogenesis.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.2002.tb07834.x</identifier><identifier>PMID: 12352527</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Biological and medical sciences ; Colon - pathology ; Colon - surgery ; Colonic Diseases - complications ; Colonic Diseases - pathology ; Colonic Diseases - surgery ; Cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - pathology ; Dietary Supplements - adverse effects ; Errors of metabolism ; Fibrosing colonopathy ; Humans ; Infant, Newborn ; Intestinal Obstruction - pathology ; Male ; Meconium ; Medical sciences ; Metabolic diseases ; Miscellaneous hereditary metabolic disorders ; Neonate ; Pancreatin - adverse effects</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2002-09, Vol.35 (3), p.356-359</ispartof><rights>2002 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2002 Lippincott Williams & Wilkins, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2972-5c5c9c804726e87327d7797d32ace93659c3f96cad4efa2ad4e21176cccab843</citedby><cites>FETCH-LOGICAL-c2972-5c5c9c804726e87327d7797d32ace93659c3f96cad4efa2ad4e21176cccab843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1536-4801.2002.tb07834.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1536-4801.2002.tb07834.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13925528$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12352527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serban, Daniela Elena</creatorcontrib><creatorcontrib>Florescu, Petre</creatorcontrib><creatorcontrib>Miu, Nicolae</creatorcontrib><title>Fibrosing Colonopathy Revealing Cystic Fibrosis In A Neonate Before Any Pancreatic Enzyme Supplementation</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Although its pathogenesis remains still unknown, fibrosing colonopathy (FCP) is considered to be the result of prolonged treatment by high doses of pancreatic enzyme preparations, in a small proportion of patients who present with cystic fibrosis (CF). We present the case of a newborn with meconium ileus (treated by conservative measures), in which, at the age of 3 weeks, the features of intestinal obstruction made necessary the removal of 15 cm of the proximal large intestine. Macroscopical and especially microscopical appearances typical for FCP were found, despite the absence of any enzymatic treatment. These findings raised the suspicion of CF, which was confirmed 4 weeks later at necropsy by the presence of characteristic pancreatic lesions. This case and another similar report in the literature suggest that the mechanism of FCP must be linked with the disease itself, at least in some patients. Thus, for us, FCP is not a “closed subject” and we sustain the importance of continuing studies, which will shed light on its etiopathogenesis.</description><subject>Biological and medical sciences</subject><subject>Colon - pathology</subject><subject>Colon - surgery</subject><subject>Colonic Diseases - complications</subject><subject>Colonic Diseases - pathology</subject><subject>Colonic Diseases - surgery</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - pathology</subject><subject>Dietary Supplements - adverse effects</subject><subject>Errors of metabolism</subject><subject>Fibrosing colonopathy</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intestinal Obstruction - pathology</subject><subject>Male</subject><subject>Meconium</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Miscellaneous hereditary metabolic disorders</subject><subject>Neonate</subject><subject>Pancreatin - adverse effects</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc1u1DAUhS0EokPhFZCFBLsE_8Rxwm466kBRVSro3vJ4bpgMjh3shDY8PQ4T0TUL68rX3_H1OUboDSU5JYS9P-ZU8DIrKkJzlhr5sCOy4kX-8ASt_h09RSvCpMwYpeUZehHjkRAiC0GeozPKuGCCyRVqt-0u-Ni673jjrXe-18Nhwl_hF2j7tzvFoTV4wSK-cniNb8A7PQC-gMYHwGs34VvtTAA9s5fu99QB_jb2vYUO3JC63r1EzxptI7xa6jm6217ebT5l118-Xm3W15lhtWSZMMLUpiKFZCVUkjO5l7KWe860gZqXoja8qUuj9wU0ms0lOZSlMUbvqoKfo3ena_vgf44QB9W10YC12oEfo5IsmSekTOCHE2iSsRigUX1oOx0mRYmac1ZHNYep5jDVnLNaclYPSfx6mTLuOtg_SpdgE_B2AXQ02jYhxdPGR47XTAhWJa44cffeDhDiDzveQ1CHlP5wUOnHiEjmsnk8qdMuS4uxJNssstbC9B8vV59vb_jFlhLKKf8D3o6r4w</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>Serban, Daniela Elena</creator><creator>Florescu, Petre</creator><creator>Miu, Nicolae</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200209</creationdate><title>Fibrosing Colonopathy Revealing Cystic Fibrosis In A Neonate Before Any Pancreatic Enzyme Supplementation</title><author>Serban, Daniela Elena ; Florescu, Petre ; Miu, Nicolae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2972-5c5c9c804726e87327d7797d32ace93659c3f96cad4efa2ad4e21176cccab843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Colon - pathology</topic><topic>Colon - surgery</topic><topic>Colonic Diseases - complications</topic><topic>Colonic Diseases - pathology</topic><topic>Colonic Diseases - surgery</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - complications</topic><topic>Cystic Fibrosis - pathology</topic><topic>Dietary Supplements - adverse effects</topic><topic>Errors of metabolism</topic><topic>Fibrosing colonopathy</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intestinal Obstruction - pathology</topic><topic>Male</topic><topic>Meconium</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Miscellaneous hereditary metabolic disorders</topic><topic>Neonate</topic><topic>Pancreatin - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serban, Daniela Elena</creatorcontrib><creatorcontrib>Florescu, Petre</creatorcontrib><creatorcontrib>Miu, Nicolae</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serban, Daniela Elena</au><au>Florescu, Petre</au><au>Miu, Nicolae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fibrosing Colonopathy Revealing Cystic Fibrosis In A Neonate Before Any Pancreatic Enzyme Supplementation</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2002-09</date><risdate>2002</risdate><volume>35</volume><issue>3</issue><spage>356</spage><epage>359</epage><pages>356-359</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Although its pathogenesis remains still unknown, fibrosing colonopathy (FCP) is considered to be the result of prolonged treatment by high doses of pancreatic enzyme preparations, in a small proportion of patients who present with cystic fibrosis (CF). We present the case of a newborn with meconium ileus (treated by conservative measures), in which, at the age of 3 weeks, the features of intestinal obstruction made necessary the removal of 15 cm of the proximal large intestine. Macroscopical and especially microscopical appearances typical for FCP were found, despite the absence of any enzymatic treatment. These findings raised the suspicion of CF, which was confirmed 4 weeks later at necropsy by the presence of characteristic pancreatic lesions. This case and another similar report in the literature suggest that the mechanism of FCP must be linked with the disease itself, at least in some patients. Thus, for us, FCP is not a “closed subject” and we sustain the importance of continuing studies, which will shed light on its etiopathogenesis.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>12352527</pmid><doi>10.1002/j.1536-4801.2002.tb07834.x</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; Wiley Online Library All Journals |
| subjects | Biological and medical sciences Colon - pathology Colon - surgery Colonic Diseases - complications Colonic Diseases - pathology Colonic Diseases - surgery Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - pathology Dietary Supplements - adverse effects Errors of metabolism Fibrosing colonopathy Humans Infant, Newborn Intestinal Obstruction - pathology Male Meconium Medical sciences Metabolic diseases Miscellaneous hereditary metabolic disorders Neonate Pancreatin - adverse effects |
| title | Fibrosing Colonopathy Revealing Cystic Fibrosis In A Neonate Before Any Pancreatic Enzyme Supplementation |
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