PERMEABILITY OF GLYCOSIDES THROUGH HUMAN ERYTHROCYTE MEMBRANE
The permeability of glycosides (arbutin, salicin, glycyrritin, p-nitrophenyl-β-D-glucopyranoside, p-nitrophenyl-β-D-galactopyranoside, p-nitrophenyl-β-D-lactopyranoside, p-nitrophenyl-β-D-maltopyranoside) and their aglycons through human erythrocyte membrane was investigated. The glycosides permeate...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1991/05/25, Vol.39(5), pp.1346-1348 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | MATSUMOTO, Yasuhiro OHSAKO, Masahiko SAKATA, Ritsu |
| description | The permeability of glycosides (arbutin, salicin, glycyrritin, p-nitrophenyl-β-D-glucopyranoside, p-nitrophenyl-β-D-galactopyranoside, p-nitrophenyl-β-D-lactopyranoside, p-nitrophenyl-β-D-maltopyranoside) and their aglycons through human erythrocyte membrane was investigated. The glycosides permeated slowly, compared with their aglycons. Glycoside having disaccharide did not permeate the erythrocyte membrane. This suggested that the introduction of disaccharide to a drug significantly depresses the permeability of glycoside through erythrocyte membrane. The drug entrapped in erythrocytes was not released into the outer medium. |
| doi_str_mv | 10.1248/cpb.39.1346 |
| format | Article |
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The glycosides permeated slowly, compared with their aglycons. Glycoside having disaccharide did not permeate the erythrocyte membrane. This suggested that the introduction of disaccharide to a drug significantly depresses the permeability of glycoside through erythrocyte membrane. The drug entrapped in erythrocytes was not released into the outer medium.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.39.1346</identifier><identifier>PMID: 1914012</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>aglycon ; Biological and medical sciences ; Cell Membrane Permeability ; disaccharide ; drug delivery system ; Erythrocyte Membrane - metabolism ; erythrocytes ; General pharmacology ; glycoside ; Glycosides - blood ; glycyrritin ; human erythrocyte ; Humans ; In Vitro Techniques ; Medical sciences ; p-nitrophenyl- beta -D-galactopyranoside ; p-nitrophenyl- beta -D-glucopyranoside ; p-nitrophenyl- beta -D-maltopyranoside ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; salicin ; targetting ; transport</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1991/05/25, Vol.39(5), pp.1346-1348</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c638t-9390ef681a462e26cbd32c2fb3466b0b62b313714776ea21251c3ed721d5ba663</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4983397$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1914012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATSUMOTO, Yasuhiro</creatorcontrib><creatorcontrib>OHSAKO, Masahiko</creatorcontrib><creatorcontrib>SAKATA, Ritsu</creatorcontrib><title>PERMEABILITY OF GLYCOSIDES THROUGH HUMAN ERYTHROCYTE MEMBRANE</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The permeability of glycosides (arbutin, salicin, glycyrritin, p-nitrophenyl-β-D-glucopyranoside, p-nitrophenyl-β-D-galactopyranoside, p-nitrophenyl-β-D-lactopyranoside, p-nitrophenyl-β-D-maltopyranoside) and their aglycons through human erythrocyte membrane was investigated. The glycosides permeated slowly, compared with their aglycons. Glycoside having disaccharide did not permeate the erythrocyte membrane. This suggested that the introduction of disaccharide to a drug significantly depresses the permeability of glycoside through erythrocyte membrane. The drug entrapped in erythrocytes was not released into the outer medium.</description><subject>aglycon</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane Permeability</subject><subject>disaccharide</subject><subject>drug delivery system</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>erythrocytes</subject><subject>General pharmacology</subject><subject>glycoside</subject><subject>Glycosides - blood</subject><subject>glycyrritin</subject><subject>human erythrocyte</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>p-nitrophenyl- beta -D-galactopyranoside</subject><subject>p-nitrophenyl- beta -D-glucopyranoside</subject><subject>p-nitrophenyl- beta -D-maltopyranoside</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>salicin</subject><subject>targetting</subject><subject>transport</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0EKqUwMSNlQCwoxfZNnHhgSNO0jdQHStOhk-W4DhSlD-J24N-TKFU7svhK_o7uufoQeiS4S6jjv6l91gXeJeCwK9Suhme7lMI1amOMuU2BwS26M-YbY-piD1qoRThxMKFt9P4RJZMo6MXjOF1as4E1HC_D2TzuR3MrHSWzxXBkjRaTYGpFybL-CJdpZE2iSS8JptE9usllYfTDaXbQYhCl4cgez4ZxGIxtxcA_2Bw41jnziXQY1ZSpbAVU0TyrLmYZzhjNgIBHHM9jWlJCXaJArzxKVm4mGYMOemn27svdz1Gbg9isjdJFIbd6dzSiIinljvsvSBhmbqWqwNcGVOXOmFLnYl-uN7L8FQSLulVRtSqAi7rVin46rT1mG726sE2NVf58yqVRsshLuVVrc8Yc7gPwWtpvsG9zkJ_6nMvysFaFrpWEu36tdZuntl_iL1kKvYU_wL6PtQ</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>MATSUMOTO, Yasuhiro</creator><creator>OHSAKO, Masahiko</creator><creator>SAKATA, Ritsu</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>PERMEABILITY OF GLYCOSIDES THROUGH HUMAN ERYTHROCYTE MEMBRANE</title><author>MATSUMOTO, Yasuhiro ; OHSAKO, Masahiko ; SAKATA, Ritsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c638t-9390ef681a462e26cbd32c2fb3466b0b62b313714776ea21251c3ed721d5ba663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>aglycon</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane Permeability</topic><topic>disaccharide</topic><topic>drug delivery system</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>erythrocytes</topic><topic>General pharmacology</topic><topic>glycoside</topic><topic>Glycosides - blood</topic><topic>glycyrritin</topic><topic>human erythrocyte</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>p-nitrophenyl- beta -D-galactopyranoside</topic><topic>p-nitrophenyl- beta -D-glucopyranoside</topic><topic>p-nitrophenyl- beta -D-maltopyranoside</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>salicin</topic><topic>targetting</topic><topic>transport</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATSUMOTO, Yasuhiro</creatorcontrib><creatorcontrib>OHSAKO, Masahiko</creatorcontrib><creatorcontrib>SAKATA, Ritsu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATSUMOTO, Yasuhiro</au><au>OHSAKO, Masahiko</au><au>SAKATA, Ritsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PERMEABILITY OF GLYCOSIDES THROUGH HUMAN ERYTHROCYTE MEMBRANE</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1991</date><risdate>1991</risdate><volume>39</volume><issue>5</issue><spage>1346</spage><epage>1348</epage><pages>1346-1348</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>The permeability of glycosides (arbutin, salicin, glycyrritin, p-nitrophenyl-β-D-glucopyranoside, p-nitrophenyl-β-D-galactopyranoside, p-nitrophenyl-β-D-lactopyranoside, p-nitrophenyl-β-D-maltopyranoside) and their aglycons through human erythrocyte membrane was investigated. The glycosides permeated slowly, compared with their aglycons. Glycoside having disaccharide did not permeate the erythrocyte membrane. This suggested that the introduction of disaccharide to a drug significantly depresses the permeability of glycoside through erythrocyte membrane. The drug entrapped in erythrocytes was not released into the outer medium.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>1914012</pmid><doi>10.1248/cpb.39.1346</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 1991/05/25, Vol.39(5), pp.1346-1348 |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | aglycon Biological and medical sciences Cell Membrane Permeability disaccharide drug delivery system Erythrocyte Membrane - metabolism erythrocytes General pharmacology glycoside Glycosides - blood glycyrritin human erythrocyte Humans In Vitro Techniques Medical sciences p-nitrophenyl- beta -D-galactopyranoside p-nitrophenyl- beta -D-glucopyranoside p-nitrophenyl- beta -D-maltopyranoside Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments salicin targetting transport |
| title | PERMEABILITY OF GLYCOSIDES THROUGH HUMAN ERYTHROCYTE MEMBRANE |
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