Prevention of bile acid–induced apoptosis by betaine in rat liver

Bile acid–induced apoptosis plays an important role in the pathogenesis of cholestatic liver disease, and its prevention is of therapeutic interest. The effects of betaine were studied on taurolithocholate 3-sulfate (TLCS) and glycochenodeoxycholate (GCDC)-induced apoptosis in rat hepatocytes in vit...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2002-10, Vol.36 (4), p.829-839
Hauptverfasser:	Graf, Dirk, Kurz, Anna Kordelia, Reinehr, Roland, Fischer, Richard, Kircheis, Gerald, Häussinger, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Betaine - pharmacology Bile Acids and Salts - pharmacology Biological and medical sciences Cell Membrane - metabolism Cells, Cultured Cholestasis - drug therapy Cholestasis - pathology Digestive system fas Receptor - metabolism Glycochenodeoxycholic Acid - pharmacology Hepatocytes - cytology In Vitro Techniques Ligation Lipotropic Agents - pharmacology Liver Diseases - drug therapy Liver Diseases - pathology Male Medical sciences Oxidative Stress - drug effects Pharmacology. Drug treatments Rats Rats, Wistar Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor - metabolism Signal Transduction - drug effects Taurolithocholic Acid - analogs & derivatives Taurolithocholic Acid - pharmacology
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