Role of tumour necrosis factor-α in insulin resistance during normal pregnancy
Objective: Role of tumour necrosis factor-α (TNF-α) was studied in insulin resistance during pregnancy. Study design: Serum TNF-α (ELISA) and fasting C-peptide (Cp) (RIA) concentrations were measured in 40 healthy pregnant women (15, 12 and 13 of them in the 1st, 2nd and 3rd trimesters, respectively...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2002-10, Vol.105 (1), p.7-10 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Melczer, Zs Bánhidy, F Csömör, S Kovács, M Siklós, P Winkler, G Cseh, K |
| description | Objective: Role of tumour necrosis factor-α (TNF-α) was studied in insulin resistance during pregnancy.
Study design: Serum TNF-α (ELISA) and fasting C-peptide (Cp) (RIA) concentrations were measured in 40 healthy pregnant women (15, 12 and 13 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 25 healthy non-pregnant women in a case-control study.
Results: TNF-α (
X±S.D.: 5.33±0.46
pg/ml) and Cp levels (3.37±1.30
ng/ml) were significantly higher in the 3rd trimester as compared with matched healthy controls (TNF: 4.07±0.26, Cp: 1.05±0.36) and to the pregnant women in 1st (TNF: 4.04±0.26, Cp: 1.34±0.59) and 2nd (TNF: 4.35±0.32, Cp: 1.11±0.35) trimesters. Significant positive linear correlation was calculated among TNF-α, Cp, Cp/blood glucose ratio (indirect parameters of insulin resistance) and body mass indexes (BMIs) of pregnant women (
P |
| doi_str_mv | 10.1016/S0301-2115(02)00108-2 |
| format | Article |
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Study design: Serum TNF-α (ELISA) and fasting C-peptide (Cp) (RIA) concentrations were measured in 40 healthy pregnant women (15, 12 and 13 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 25 healthy non-pregnant women in a case-control study.
Results: TNF-α (
X±S.D.: 5.33±0.46
pg/ml) and Cp levels (3.37±1.30
ng/ml) were significantly higher in the 3rd trimester as compared with matched healthy controls (TNF: 4.07±0.26, Cp: 1.05±0.36) and to the pregnant women in 1st (TNF: 4.04±0.26, Cp: 1.34±0.59) and 2nd (TNF: 4.35±0.32, Cp: 1.11±0.35) trimesters. Significant positive linear correlation was calculated among TNF-α, Cp, Cp/blood glucose ratio (indirect parameters of insulin resistance) and body mass indexes (BMIs) of pregnant women (
P<0.01).
Conclusion: TNF-α may contribute to the insulin resistance during the course of normal pregnancy.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/S0301-2115(02)00108-2</identifier><identifier>PMID: 12270556</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Pressure ; Body Constitution ; Body Mass Index ; C-Peptide - blood ; Case-Control Studies ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Insulin Resistance ; Medical sciences ; Pregnancy ; Pregnancy Complications ; Pregnancy Trimester, Third ; Pregnancy. Fetus. Placenta ; TNF-α ; Tumor Necrosis Factor-alpha - analysis ; Tumor Necrosis Factor-alpha - physiology</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2002-10, Vol.105 (1), p.7-10</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-6de58a9782fbb9bbc566de58c3c8f684d69450f6564f598d40c9c6a2ac9bee43</citedby><cites>FETCH-LOGICAL-c391t-6de58a9782fbb9bbc566de58c3c8f684d69450f6564f598d40c9c6a2ac9bee43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0301-2115(02)00108-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13941488$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12270556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Melczer, Zs</creatorcontrib><creatorcontrib>Bánhidy, F</creatorcontrib><creatorcontrib>Csömör, S</creatorcontrib><creatorcontrib>Kovács, M</creatorcontrib><creatorcontrib>Siklós, P</creatorcontrib><creatorcontrib>Winkler, G</creatorcontrib><creatorcontrib>Cseh, K</creatorcontrib><title>Role of tumour necrosis factor-α in insulin resistance during normal pregnancy</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Objective: Role of tumour necrosis factor-α (TNF-α) was studied in insulin resistance during pregnancy.
Study design: Serum TNF-α (ELISA) and fasting C-peptide (Cp) (RIA) concentrations were measured in 40 healthy pregnant women (15, 12 and 13 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 25 healthy non-pregnant women in a case-control study.
Results: TNF-α (
X±S.D.: 5.33±0.46
pg/ml) and Cp levels (3.37±1.30
ng/ml) were significantly higher in the 3rd trimester as compared with matched healthy controls (TNF: 4.07±0.26, Cp: 1.05±0.36) and to the pregnant women in 1st (TNF: 4.04±0.26, Cp: 1.34±0.59) and 2nd (TNF: 4.35±0.32, Cp: 1.11±0.35) trimesters. Significant positive linear correlation was calculated among TNF-α, Cp, Cp/blood glucose ratio (indirect parameters of insulin resistance) and body mass indexes (BMIs) of pregnant women (
P<0.01).
Conclusion: TNF-α may contribute to the insulin resistance during the course of normal pregnancy.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Constitution</subject><subject>Body Mass Index</subject><subject>C-Peptide - blood</subject><subject>Case-Control Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy Trimester, Third</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>TNF-α</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOl4eQelG0UU1SZs0WYmINxAGdPYhTU8k0jZj0grzWL6Iz2Tmgi4NgQMn30nyfwgdE3xJMOFXr7jAJKeEsHNMLzAmWOR0C02IqGhecVZuo8kvsof2Y3zHaRWF3EV7hNIKM8YnaPriW8i8zYax82PIejDBRxczq83gQ_79lbk-7Ti2qQZIR4PuDWTNGFz_lvU-dLrN5gHe-tRfHKIdq9sIR5t6gGb3d7Pbx_x5-vB0e_Ocm0KSIecNMKFlJaita1nXhvFVyxRGWC7KhsuSYcsZLy2ToimxkYZrqo2sAcriAJ2tr50H_zFCHFTnooG21T34MaqKpohFRRPI1uAyVgxg1Ty4ToeFIlgtRaqVSLW0pDBVK5FqOXeyeWCsO2j-pjbmEnC6AXQ0urUhpXfxjytkSUohEne95iDZ-HQQVDQOksHGBTCDarz75ys_7xGQwg</recordid><startdate>20021010</startdate><enddate>20021010</enddate><creator>Melczer, Zs</creator><creator>Bánhidy, F</creator><creator>Csömör, S</creator><creator>Kovács, M</creator><creator>Siklós, P</creator><creator>Winkler, G</creator><creator>Cseh, K</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021010</creationdate><title>Role of tumour necrosis factor-α in insulin resistance during normal pregnancy</title><author>Melczer, Zs ; Bánhidy, F ; Csömör, S ; Kovács, M ; Siklós, P ; Winkler, G ; Cseh, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-6de58a9782fbb9bbc566de58c3c8f684d69450f6564f598d40c9c6a2ac9bee43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body Constitution</topic><topic>Body Mass Index</topic><topic>C-Peptide - blood</topic><topic>Case-Control Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy Trimester, Third</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>TNF-α</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Tumor Necrosis Factor-alpha - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melczer, Zs</creatorcontrib><creatorcontrib>Bánhidy, F</creatorcontrib><creatorcontrib>Csömör, S</creatorcontrib><creatorcontrib>Kovács, M</creatorcontrib><creatorcontrib>Siklós, P</creatorcontrib><creatorcontrib>Winkler, G</creatorcontrib><creatorcontrib>Cseh, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melczer, Zs</au><au>Bánhidy, F</au><au>Csömör, S</au><au>Kovács, M</au><au>Siklós, P</au><au>Winkler, G</au><au>Cseh, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of tumour necrosis factor-α in insulin resistance during normal pregnancy</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2002-10-10</date><risdate>2002</risdate><volume>105</volume><issue>1</issue><spage>7</spage><epage>10</epage><pages>7-10</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Objective: Role of tumour necrosis factor-α (TNF-α) was studied in insulin resistance during pregnancy.
Study design: Serum TNF-α (ELISA) and fasting C-peptide (Cp) (RIA) concentrations were measured in 40 healthy pregnant women (15, 12 and 13 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 25 healthy non-pregnant women in a case-control study.
Results: TNF-α (
X±S.D.: 5.33±0.46
pg/ml) and Cp levels (3.37±1.30
ng/ml) were significantly higher in the 3rd trimester as compared with matched healthy controls (TNF: 4.07±0.26, Cp: 1.05±0.36) and to the pregnant women in 1st (TNF: 4.04±0.26, Cp: 1.34±0.59) and 2nd (TNF: 4.35±0.32, Cp: 1.11±0.35) trimesters. Significant positive linear correlation was calculated among TNF-α, Cp, Cp/blood glucose ratio (indirect parameters of insulin resistance) and body mass indexes (BMIs) of pregnant women (
P<0.01).
Conclusion: TNF-α may contribute to the insulin resistance during the course of normal pregnancy.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>12270556</pmid><doi>10.1016/S0301-2115(02)00108-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2002-10, Vol.105 (1), p.7-10 |
| issn | 0301-2115 1872-7654 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Biological and medical sciences Blood Pressure Body Constitution Body Mass Index C-Peptide - blood Case-Control Studies Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Insulin Resistance Medical sciences Pregnancy Pregnancy Complications Pregnancy Trimester, Third Pregnancy. Fetus. Placenta TNF-α Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - physiology |
| title | Role of tumour necrosis factor-α in insulin resistance during normal pregnancy |
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