Cloning and chromosomal localization of MYO15A to chromosome 5 of the dog (Canis familiaris)
Mutations in the myosin XVA gene (MYO15A) cause congenital non-syndromic deafness in humans and mice. Therefore, the M YO15A gene represents a candidate gene for hereditary hearing loss in dogs. Using a human cDNA to screen a dog BAC library, we isolated a canine BAC clone. Sequencing of the BAC end...
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| Veröffentlicht in: | Chromosome research 2002-01, Vol.10 (5), p.407-410 |
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| container_title | Chromosome research |
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| creator | Rak, Simone G Drögemüller, Cord Kuiper, Heidi Leeb, Tosso Quignon, Pascale André, Catherine Distl, Ottmar |
| description | Mutations in the myosin XVA gene (MYO15A) cause congenital non-syndromic deafness in humans and mice. Therefore, the M YO15A gene represents a candidate gene for hereditary hearing loss in dogs. Using a human cDNA to screen a dog BAC library, we isolated a canine BAC clone. Sequencing of the BAC ends confirmed homology to the human gene. To facilitate future linkage studies, we report the physical mapping of the canine MYO15A gene to CFA5q23-q24 by FISH and RH mapping. |
| doi_str_mv | 10.1023/A:1016805803686 |
| format | Article |
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Therefore, the M YO15A gene represents a candidate gene for hereditary hearing loss in dogs. Using a human cDNA to screen a dog BAC library, we isolated a canine BAC clone. Sequencing of the BAC ends confirmed homology to the human gene. 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Therefore, the M YO15A gene represents a candidate gene for hereditary hearing loss in dogs. Using a human cDNA to screen a dog BAC library, we isolated a canine BAC clone. Sequencing of the BAC ends confirmed homology to the human gene. To facilitate future linkage studies, we report the physical mapping of the canine MYO15A gene to CFA5q23-q24 by FISH and RH mapping.</description><subject>Animals</subject><subject>Bacterial artificial chromosomes</subject><subject>Canis familiaris</subject><subject>Chromosome 5</subject><subject>Chromosome Banding</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Deafness</subject><subject>Dogs</subject><subject>Gene mapping</subject><subject>Genes</subject><subject>Genetics</subject><subject>Genome</subject><subject>Hearing loss</subject><subject>Hearing Loss, Sensorineural - genetics</subject><subject>Homology</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Localization</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Myosin</subject><subject>Myosins - genetics</subject><subject>Physical Chromosome Mapping</subject><subject>Physical mapping</subject><subject>Radiation Hybrid Mapping</subject><issn>0967-3849</issn><issn>1573-6849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90EtLw0AQB_BFFFurZ2-yeJB6iO4j--qtBF9Q6UUPghA2m027ZZOt2eSgn96IFcGDpxmYH8P8B4BTjK4wIvR6PsMIc4mYRJRLvgfGmAmacJmqfTBGiouEDv0IHMW4QQhJmuJDMMKEKM4IHYPXzIfGNSuomxKadRvqEEOtPfTBaO8-dOdCA0MFH1-WmM1hF36Vhexr0q0tLMMKTjPduAgrXTvvdOvi5TE4qLSP9mRXJ-D59uYpu08Wy7uHbL5IDMW0SyizTA8RKi4qqiSypdICayKHaytlikojWkpdFpiblBRGiJIVxhIrhTXcFHQCLr73btvw1tvY5bWLxnqvGxv6mAuCCRYpHuD0X4gFowwpqdBAz__QTejbZoiRC4YYo5KTAZ3tUF_Utsy3rat1-57__Jd-AhBlexo</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Rak, Simone G</creator><creator>Drögemüller, Cord</creator><creator>Kuiper, Heidi</creator><creator>Leeb, Tosso</creator><creator>Quignon, Pascale</creator><creator>André, Catherine</creator><creator>Distl, Ottmar</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Cloning and chromosomal localization of MYO15A to chromosome 5 of the dog (Canis familiaris)</title><author>Rak, Simone G ; Drögemüller, Cord ; Kuiper, Heidi ; Leeb, Tosso ; Quignon, Pascale ; André, Catherine ; Distl, Ottmar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-35e5a058f67f3980ed9a71a28834f9cbfa03d8adb16c42bc77d5bce2e87ec6cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Bacterial artificial chromosomes</topic><topic>Canis familiaris</topic><topic>Chromosome 5</topic><topic>Chromosome Banding</topic><topic>Cloning</topic><topic>Cloning, Molecular</topic><topic>Deafness</topic><topic>Dogs</topic><topic>Gene mapping</topic><topic>Genes</topic><topic>Genetics</topic><topic>Genome</topic><topic>Hearing loss</topic><topic>Hearing Loss, Sensorineural - genetics</topic><topic>Homology</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Localization</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Myosin</topic><topic>Myosins - genetics</topic><topic>Physical Chromosome Mapping</topic><topic>Physical mapping</topic><topic>Radiation Hybrid Mapping</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rak, Simone G</creatorcontrib><creatorcontrib>Drögemüller, Cord</creatorcontrib><creatorcontrib>Kuiper, Heidi</creatorcontrib><creatorcontrib>Leeb, Tosso</creatorcontrib><creatorcontrib>Quignon, Pascale</creatorcontrib><creatorcontrib>André, Catherine</creatorcontrib><creatorcontrib>Distl, Ottmar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chromosome research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rak, Simone G</au><au>Drögemüller, Cord</au><au>Kuiper, Heidi</au><au>Leeb, Tosso</au><au>Quignon, Pascale</au><au>André, Catherine</au><au>Distl, Ottmar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cloning and chromosomal localization of MYO15A to chromosome 5 of the dog (Canis familiaris)</atitle><jtitle>Chromosome research</jtitle><addtitle>Chromosome Res</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>10</volume><issue>5</issue><spage>407</spage><epage>410</epage><pages>407-410</pages><issn>0967-3849</issn><eissn>1573-6849</eissn><abstract>Mutations in the myosin XVA gene (MYO15A) cause congenital non-syndromic deafness in humans and mice. 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| subjects | Animals Bacterial artificial chromosomes Canis familiaris Chromosome 5 Chromosome Banding Cloning Cloning, Molecular Deafness Dogs Gene mapping Genes Genetics Genome Hearing loss Hearing Loss, Sensorineural - genetics Homology Humans In Situ Hybridization, Fluorescence Localization Molecular Sequence Data Mutation Myosin Myosins - genetics Physical Chromosome Mapping Physical mapping Radiation Hybrid Mapping |
| title | Cloning and chromosomal localization of MYO15A to chromosome 5 of the dog (Canis familiaris) |
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