The effects of tianeptine on wet-dog shakes, fore-paw treading and a flexor reflex in rats are consistent with enhancement of 5-hydroxytryptamine uptake
Tianeptine is a novel antidepressant which uniquely facilitates 5-hydroxytryptamine (5-HT) uptake. When given in a dose of 10 mg/kg to rats pretreated with either carbidopa or phenelzine, it markedly reduced the frequency of wet-dog shakes, fore-paw treading, tremor and hind-limb abduction evoked by...
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| Veröffentlicht in: | European journal of pharmacology 1991-05, Vol.198 (1), p.51-57 |
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| creator | Koshikawa, Noriaki Mocaër, Elisabeth Stephenson, John D. |
| description | Tianeptine is a novel antidepressant which uniquely facilitates 5-hydroxytryptamine (5-HT) uptake. When given in a dose of 10 mg/kg to rats pretreated with either carbidopa or phenelzine, it markedly reduced the frequency of wet-dog shakes, fore-paw treading, tremor and hind-limb abduction evoked by L-5-hydroxytryptophan (L-5-HTP) given 30 or 60 min later. This effect of tianeptine was opposite to that of paroxetine, a selective 5-HT uptake inhibitor, which greatly increased the 5-HTP-induced behavioural syndrome. In contrast, tianeptine did not affect behaviours elicited by the 5-HT receptor agonists, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) or (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), which are not substrates for the 5-HT uptake process. In spinal animals, tianeptine attenuated an ipsilateral flexor reflex, an effect opposite to that of citalopram, a selective 5-HT uptake inhibitor. These effects of tianeptine are consistent with its ability to increase 5-HT reuptake. Tianeptine; L-5-Hydroxytryptophan (L-5-HTP); 5-HT behavioural syndrome; 5-HT uptake inhibition; Flexor reflex; Paroxetine |
| doi_str_mv | 10.1016/0014-2999(91)90561-4 |
| format | Article |
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Drug treatments ; Phenelzine - pharmacology ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. 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When given in a dose of 10 mg/kg to rats pretreated with either carbidopa or phenelzine, it markedly reduced the frequency of wet-dog shakes, fore-paw treading, tremor and hind-limb abduction evoked by L-5-hydroxytryptophan (L-5-HTP) given 30 or 60 min later. This effect of tianeptine was opposite to that of paroxetine, a selective 5-HT uptake inhibitor, which greatly increased the 5-HTP-induced behavioural syndrome. In contrast, tianeptine did not affect behaviours elicited by the 5-HT receptor agonists, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) or (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), which are not substrates for the 5-HT uptake process. In spinal animals, tianeptine attenuated an ipsilateral flexor reflex, an effect opposite to that of citalopram, a selective 5-HT uptake inhibitor. These effects of tianeptine are consistent with its ability to increase 5-HT reuptake. Tianeptine; L-5-Hydroxytryptophan (L-5-HTP); 5-HT behavioural syndrome; 5-HT uptake inhibition; Flexor reflex; Paroxetine</description><subject>Amphetamines - pharmacology</subject><subject>Animals</subject><subject>Antidepressive Agents, Tricyclic - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Carbidopa - pharmacology</subject><subject>Decerebrate State</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electric Stimulation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methoxydimethyltryptamines - pharmacology</subject><subject>Muscle Contraction - drug effects</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenelzine - pharmacology</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reflex - drug effects</subject><subject>Serotonin - metabolism</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - physiology</subject><subject>Thiazepines - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-OFCEQxonRrOPqG2jCRaOJrVTTTDcXE7PxX7KJl_VMGCi2cbthBMbZeRMfV9qZqCc9UaF-9RV8HyGPgb0CBuvXjEHXtFLK5xJeSCbW0HR3yAqGXjash_YuWf1G7pMHOX9ljAnZijNyBhKE6IcV-XE1IkXn0JRMo6PF64Db4gPSGOgeS2PjNc2jvsH8krqYsNnqPS0JtfXhmupgqaZuwtuYaMKloD7QpKucTkhNDNnngqHQvS8jxTDqYHBeLuo60YwHm-LtoaTDtuh52burxQ0-JPecnjI-Op3n5Mv7d1cXH5vLzx8-Xby9bEwHQ2k2klsuBnADMjE4CwLZRspN_R2YoV-jMNpZJ1uuHdauc5yttatOaM644_ycPDvqblP8tsNc1OyzwWmqPsRdVn0LLRug_y8IQvat6GUFuyNoUsy5eqK2yc86HRQwtSSnlljUEouSoH4lp7o69uSkv9vMaP8MHaOq_aenvs5GTy5VH33-C-uF5HzReXPksLr23WNS2XisnlufasrKRv_vh_wEZGC3bg</recordid><startdate>19910530</startdate><enddate>19910530</enddate><creator>Koshikawa, Noriaki</creator><creator>Mocaër, Elisabeth</creator><creator>Stephenson, John D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19910530</creationdate><title>The effects of tianeptine on wet-dog shakes, fore-paw treading and a flexor reflex in rats are consistent with enhancement of 5-hydroxytryptamine uptake</title><author>Koshikawa, Noriaki ; Mocaër, Elisabeth ; Stephenson, John D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-b93d3581f8e058fd15e0b99b5571c876e5cafdf923afed15ff306af000a303f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Amphetamines - pharmacology</topic><topic>Animals</topic><topic>Antidepressive Agents, Tricyclic - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Carbidopa - pharmacology</topic><topic>Decerebrate State</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electric Stimulation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methoxydimethyltryptamines - pharmacology</topic><topic>Muscle Contraction - drug effects</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenelzine - pharmacology</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reflex - drug effects</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - physiology</topic><topic>Thiazepines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koshikawa, Noriaki</creatorcontrib><creatorcontrib>Mocaër, Elisabeth</creatorcontrib><creatorcontrib>Stephenson, John D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koshikawa, Noriaki</au><au>Mocaër, Elisabeth</au><au>Stephenson, John D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of tianeptine on wet-dog shakes, fore-paw treading and a flexor reflex in rats are consistent with enhancement of 5-hydroxytryptamine uptake</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1991-05-30</date><risdate>1991</risdate><volume>198</volume><issue>1</issue><spage>51</spage><epage>57</epage><pages>51-57</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Tianeptine is a novel antidepressant which uniquely facilitates 5-hydroxytryptamine (5-HT) uptake. When given in a dose of 10 mg/kg to rats pretreated with either carbidopa or phenelzine, it markedly reduced the frequency of wet-dog shakes, fore-paw treading, tremor and hind-limb abduction evoked by L-5-hydroxytryptophan (L-5-HTP) given 30 or 60 min later. This effect of tianeptine was opposite to that of paroxetine, a selective 5-HT uptake inhibitor, which greatly increased the 5-HTP-induced behavioural syndrome. In contrast, tianeptine did not affect behaviours elicited by the 5-HT receptor agonists, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) or (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), which are not substrates for the 5-HT uptake process. In spinal animals, tianeptine attenuated an ipsilateral flexor reflex, an effect opposite to that of citalopram, a selective 5-HT uptake inhibitor. These effects of tianeptine are consistent with its ability to increase 5-HT reuptake. Tianeptine; L-5-Hydroxytryptophan (L-5-HTP); 5-HT behavioural syndrome; 5-HT uptake inhibition; Flexor reflex; Paroxetine</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1915578</pmid><doi>10.1016/0014-2999(91)90561-4</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of pharmacology, 1991-05, Vol.198 (1), p.51-57 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amphetamines - pharmacology Animals Antidepressive Agents, Tricyclic - pharmacology Behavior, Animal - drug effects Biological and medical sciences Carbidopa - pharmacology Decerebrate State Dose-Response Relationship, Drug Electric Stimulation Male Medical sciences Methoxydimethyltryptamines - pharmacology Muscle Contraction - drug effects Neuropharmacology Pharmacology. Drug treatments Phenelzine - pharmacology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Reflex - drug effects Serotonin - metabolism Serotonin Antagonists - pharmacology Spinal Cord - drug effects Spinal Cord - physiology Thiazepines - pharmacology |
| title | The effects of tianeptine on wet-dog shakes, fore-paw treading and a flexor reflex in rats are consistent with enhancement of 5-hydroxytryptamine uptake |
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