Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease
Evidence for an association between Chlamydia pneumoniae infection and coronary artery disease (CAD) has been reported by numerous studies, cross-reactive heat shock protein (Hsp) antibody responses have been causally linked to CAD, and the severity of chlamydial disease pathogenesis correlates with...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2002-09, Vol.106 (13), p.1659-1663 |
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| creator | MAHDI, Olaimatu S HORNE, Benjamin D MULLEN, Kelly MUHLESTEIN, Joseph B BYRNE, Gerald I |
| description | Evidence for an association between Chlamydia pneumoniae infection and coronary artery disease (CAD) has been reported by numerous studies, cross-reactive heat shock protein (Hsp) antibody responses have been causally linked to CAD, and the severity of chlamydial disease pathogenesis correlates with Hsp serology. Our aim was to determine if chlamydial Hsp (cHsp) antibody responses are predictive of CAD.
Patients were recruited in a case-control study: 250 cases had angiographically significant CAD (stenosis > or =70%), and 250 controls had normal coronary arteries (stenosis |
| doi_str_mv | 10.1161/01.CIR.0000031567.10814.D8 |
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Patients were recruited in a case-control study: 250 cases had angiographically significant CAD (stenosis > or =70%), and 250 controls had normal coronary arteries (stenosis <10%). Serum immunoglobulin G reactivity to Hsp10 and Hsp60 antigens (chlamydial, Escherichia coli, and human), and C pneumoniae whole organisms were measured by ELISA. Univariate analysis confirmed that classical CAD risk factors were predictors of CAD. Univariate analysis showed that cHsp60 (P= 0.001, OR 3.9), cHsp10 (P=0.045, OR 3.8), E coli Hsp60 (P=0.04, OR 1.5) and C pneumoniae (P=0.03, OR 1.8) ELISA optical density (OD) values were significantly different between cases and controls. Multivariate analysis found that only upper-quintile cHsp60 seroreactivity remained a significant predictor of CAD after controlling for classical CAD risk factors and seroreactivity to the other antigens (cHsp60 OD, P=0.005, OR 3.9 per OD unit; cHsp60 quintile, 5 versus 1 to 4; P=0.01, OR 2.1).
The presence of elevated anti-cHsp60 immunoglobulin G antibodies, but not anti-human or anti-E coli homologs, was independently associated with CAD. This finding argues against previous suggestions that cross-reactive or autoimmune Hsp60 responses may contribute to disease progression. High anti-cHsp60 antibody response appears to identify the subset of patients with chlamydial infection and significant CAD.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000031567.10814.D8</identifier><identifier>PMID: 12270859</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Antibodies, Bacterial - blood ; Autoimmunity - immunology ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Chaperonin 60 - immunology ; Chlamydophila Infections - blood ; Chlamydophila Infections - epidemiology ; Chlamydophila Infections - immunology ; Chlamydophila pneumoniae - immunology ; Comorbidity ; Coronary Artery Disease - blood ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - immunology ; Coronary heart disease ; Cross Reactions - immunology ; Demography ; Disease Progression ; Female ; Heart ; HeLa Cells ; Humans ; Immunoglobulin G - blood ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Predictive Value of Tests ; Risk Factors ; Seroepidemiologic Studies ; Utah - epidemiology</subject><ispartof>Circulation (New York, N.Y.), 2002-09, Vol.106 (13), p.1659-1663</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Sep 24, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-f7c8cbc0b336c676d1d0c8671eb1b0541abb5cd6126842d68a63ef4d2639e4523</citedby><cites>FETCH-LOGICAL-c496t-f7c8cbc0b336c676d1d0c8671eb1b0541abb5cd6126842d68a63ef4d2639e4523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13950228$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12270859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAHDI, Olaimatu S</creatorcontrib><creatorcontrib>HORNE, Benjamin D</creatorcontrib><creatorcontrib>MULLEN, Kelly</creatorcontrib><creatorcontrib>MUHLESTEIN, Joseph B</creatorcontrib><creatorcontrib>BYRNE, Gerald I</creatorcontrib><title>Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Evidence for an association between Chlamydia pneumoniae infection and coronary artery disease (CAD) has been reported by numerous studies, cross-reactive heat shock protein (Hsp) antibody responses have been causally linked to CAD, and the severity of chlamydial disease pathogenesis correlates with Hsp serology. Our aim was to determine if chlamydial Hsp (cHsp) antibody responses are predictive of CAD.
Patients were recruited in a case-control study: 250 cases had angiographically significant CAD (stenosis > or =70%), and 250 controls had normal coronary arteries (stenosis <10%). Serum immunoglobulin G reactivity to Hsp10 and Hsp60 antigens (chlamydial, Escherichia coli, and human), and C pneumoniae whole organisms were measured by ELISA. Univariate analysis confirmed that classical CAD risk factors were predictors of CAD. Univariate analysis showed that cHsp60 (P= 0.001, OR 3.9), cHsp10 (P=0.045, OR 3.8), E coli Hsp60 (P=0.04, OR 1.5) and C pneumoniae (P=0.03, OR 1.8) ELISA optical density (OD) values were significantly different between cases and controls. Multivariate analysis found that only upper-quintile cHsp60 seroreactivity remained a significant predictor of CAD after controlling for classical CAD risk factors and seroreactivity to the other antigens (cHsp60 OD, P=0.005, OR 3.9 per OD unit; cHsp60 quintile, 5 versus 1 to 4; P=0.01, OR 2.1).
The presence of elevated anti-cHsp60 immunoglobulin G antibodies, but not anti-human or anti-E coli homologs, was independently associated with CAD. This finding argues against previous suggestions that cross-reactive or autoimmune Hsp60 responses may contribute to disease progression. High anti-cHsp60 antibody response appears to identify the subset of patients with chlamydial infection and significant CAD.</description><subject>Aged</subject><subject>Antibodies, Bacterial - blood</subject><subject>Autoimmunity - immunology</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Chaperonin 60 - immunology</subject><subject>Chlamydophila Infections - blood</subject><subject>Chlamydophila Infections - epidemiology</subject><subject>Chlamydophila Infections - immunology</subject><subject>Chlamydophila pneumoniae - immunology</subject><subject>Comorbidity</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - immunology</subject><subject>Coronary heart disease</subject><subject>Cross Reactions - immunology</subject><subject>Demography</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Heart</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>Seroepidemiologic Studies</subject><subject>Utah - epidemiology</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1rFDEUhoModq3-BQkFvZsxJ5lJMt7JVmuhIPhxHfI13dSZSU0ylP0p_luz7cKCuQnhPG_OOTwIXQBpATh8INBur7-35HAY9Fy0QCR07aV8hjbQ067pejY8R5taHxrBKD1Dr3K-q0_ORP8SnQGlgsh-2KC_P3xaZxzmeV3i7RTNOoUFX2G9lGCiCz7jErHdTXreu6AnvPO64LyL9je-T7H4SnOCzVrwEsuB3a2zXmreYaNt8ekxFOc4xduMdfJY5xxt0MU7_BDKDtuY4qLTvhYrvscuZK-zf41ejHrK_s3xPke_vnz-uf3a3Hy7ut5-umlsN_DSjMJKaywxjHHLBXfgiJVcgDdgSN-BNqa3jgPlsqOOS82ZHztHORt811N2jt4__VvX-bP6XNQcsvXTpBcf16wEBRgGKSt48R94F9e01NkUBSo4kYJU6OMTZFPMOflR3acw1-0UEHWwpwioak-d7KlHe-ry0OHtscNqZu9O0aOuCrw7AjpbPY1JLzbkE8eGnlAq2T8UZKU7</recordid><startdate>20020924</startdate><enddate>20020924</enddate><creator>MAHDI, Olaimatu S</creator><creator>HORNE, Benjamin D</creator><creator>MULLEN, Kelly</creator><creator>MUHLESTEIN, Joseph B</creator><creator>BYRNE, Gerald I</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20020924</creationdate><title>Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease</title><author>MAHDI, Olaimatu S ; HORNE, Benjamin D ; MULLEN, Kelly ; MUHLESTEIN, Joseph B ; BYRNE, Gerald I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-f7c8cbc0b336c676d1d0c8671eb1b0541abb5cd6126842d68a63ef4d2639e4523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Antibodies, Bacterial - blood</topic><topic>Autoimmunity - immunology</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Chaperonin 60 - immunology</topic><topic>Chlamydophila Infections - blood</topic><topic>Chlamydophila Infections - epidemiology</topic><topic>Chlamydophila Infections - immunology</topic><topic>Chlamydophila pneumoniae - immunology</topic><topic>Comorbidity</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - immunology</topic><topic>Coronary heart disease</topic><topic>Cross Reactions - immunology</topic><topic>Demography</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Heart</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><topic>Seroepidemiologic Studies</topic><topic>Utah - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAHDI, Olaimatu S</creatorcontrib><creatorcontrib>HORNE, Benjamin D</creatorcontrib><creatorcontrib>MULLEN, Kelly</creatorcontrib><creatorcontrib>MUHLESTEIN, Joseph B</creatorcontrib><creatorcontrib>BYRNE, Gerald I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAHDI, Olaimatu S</au><au>HORNE, Benjamin D</au><au>MULLEN, Kelly</au><au>MUHLESTEIN, Joseph B</au><au>BYRNE, Gerald I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2002-09-24</date><risdate>2002</risdate><volume>106</volume><issue>13</issue><spage>1659</spage><epage>1663</epage><pages>1659-1663</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Evidence for an association between Chlamydia pneumoniae infection and coronary artery disease (CAD) has been reported by numerous studies, cross-reactive heat shock protein (Hsp) antibody responses have been causally linked to CAD, and the severity of chlamydial disease pathogenesis correlates with Hsp serology. Our aim was to determine if chlamydial Hsp (cHsp) antibody responses are predictive of CAD.
Patients were recruited in a case-control study: 250 cases had angiographically significant CAD (stenosis > or =70%), and 250 controls had normal coronary arteries (stenosis <10%). Serum immunoglobulin G reactivity to Hsp10 and Hsp60 antigens (chlamydial, Escherichia coli, and human), and C pneumoniae whole organisms were measured by ELISA. Univariate analysis confirmed that classical CAD risk factors were predictors of CAD. Univariate analysis showed that cHsp60 (P= 0.001, OR 3.9), cHsp10 (P=0.045, OR 3.8), E coli Hsp60 (P=0.04, OR 1.5) and C pneumoniae (P=0.03, OR 1.8) ELISA optical density (OD) values were significantly different between cases and controls. Multivariate analysis found that only upper-quintile cHsp60 seroreactivity remained a significant predictor of CAD after controlling for classical CAD risk factors and seroreactivity to the other antigens (cHsp60 OD, P=0.005, OR 3.9 per OD unit; cHsp60 quintile, 5 versus 1 to 4; P=0.01, OR 2.1).
The presence of elevated anti-cHsp60 immunoglobulin G antibodies, but not anti-human or anti-E coli homologs, was independently associated with CAD. This finding argues against previous suggestions that cross-reactive or autoimmune Hsp60 responses may contribute to disease progression. High anti-cHsp60 antibody response appears to identify the subset of patients with chlamydial infection and significant CAD.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12270859</pmid><doi>10.1161/01.CIR.0000031567.10814.D8</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Antibodies, Bacterial - blood Autoimmunity - immunology Biological and medical sciences Cardiology. Vascular system Case-Control Studies Chaperonin 60 - immunology Chlamydophila Infections - blood Chlamydophila Infections - epidemiology Chlamydophila Infections - immunology Chlamydophila pneumoniae - immunology Comorbidity Coronary Artery Disease - blood Coronary Artery Disease - epidemiology Coronary Artery Disease - immunology Coronary heart disease Cross Reactions - immunology Demography Disease Progression Female Heart HeLa Cells Humans Immunoglobulin G - blood Logistic Models Male Medical sciences Middle Aged Multivariate Analysis Odds Ratio Predictive Value of Tests Risk Factors Seroepidemiologic Studies Utah - epidemiology |
| title | Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease |
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