Enhancement of CD2-mediated T cell activation by the interaction of VLA-4 with fibronectin

Human fibroblasts were shown to enhance the proliferation of peripheral T cells in the presence of suboptimal concentrations of anti-CD2 antibodies (anti-T11 2 and anti-T11 3) and agonistic anti-VLA-4 antibody. Evidence is provided that the interaction of VLA-4 with immobilized fibronectin can enhan...

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Veröffentlicht in:	Cellular immunology 1991-11, Vol.138 (1), p.238-244
Hauptverfasser:	Blue, Marie-Luise, Conrad, Patricia, Davis, Gary, Kelley, Keith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antigens, Differentiation, T-Lymphocyte - physiology Biological and medical sciences CD2 Antigens Fibronectins - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Lymphocyte Activation Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Receptors, Antigen, T-Cell - physiology Receptors, Immunologic - physiology Receptors, Very Late Antigen - physiology T-Lymphocytes - immunology
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