Late Failure of Autologous Marrow Grafts in Lethally Irradiated Dogs Given Anti-Class II Monoclonal Antibody

We established a model of canine marrow autografts after 9.2 Gy total body irradiation (TBI) to study the role of class II antigens in hematopoietic stem cell growth and differentiation. Twenty dogs were given 9.2 Gy TBI, marrow, and intravenous (IV) murine anti-class II monoclonal antibody (MoAb)....

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Veröffentlicht in:	Blood 1991-10, Vol.78 (8), p.2131-2138
Hauptverfasser:	Greinix, H.T., Ladiges, W.C., Graham, T.C., Maslan, S., Raff, R.F., Sandmaier, B.M., Appelbaum, F.R., Schuening, F.G., Deeg, H.J., Storb, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Biological and medical sciences Bone Marrow Transplantation - immunology Combined Modality Therapy Dogs Female Graft Rejection - radiation effects Hematologic and hematopoietic diseases Hematopoietic Stem Cells Histocompatibility Antigens Class II - immunology Immunotherapy, Adoptive Injections, Intravenous Male Medical sciences Transplantation, Autologous Whole-Body Irradiation
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