Memory B and T Cells
Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review w...
Gespeichert in:
| Veröffentlicht in: | Annual review of immunology 1991-01, Vol.9 (1), p.193-217 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 217 |
|---|---|
| container_issue | 1 |
| container_start_page | 193 |
| container_title | Annual review of immunology |
| container_volume | 9 |
| creator | Vitetta, E S Berton, M T Burger, C Kepron, M Lee, W T Yin, X M |
| description | Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs upregulation of adhesion molecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response. |
| doi_str_mv | 10.1146/annurev.iy.09.040191.001205 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_annua</sourceid><recordid>TN_cdi_proquest_miscellaneous_72116710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16050940</sourcerecordid><originalsourceid>FETCH-LOGICAL-a434t-c63a8f3f9ed4629c6dd88f6c4e8a1df018fb0c2067289e5c1e3f9448d65fbd9e3</originalsourceid><addsrcrecordid>eNqVkElLxEAQRhtRxnH05lUIiN4Sq5d0uvGiDm4w4mU8Nz29QCTLmJ4o-fcmJKA38VSHel99xUPoHEOCMeNXuqraxn0meZeATIABljgBwATSPTTHKUtjSjKxj-aQURJDKsghOgrhHQAkpdkMzfoE8IzP0emLK-umi-4iXdloHS1dUYRjdOB1EdzJNBfo7eF-vXyKV6-Pz8vbVawZZbvYcKqFp146yziRhlsrhOeGOaGx9YCF34AhfRER0qUGu55lTFie-o2Vji7Q5Xh329QfrQs7VebB9B_oytVtUBnBmGcY_gQxhxQkG8DrETRNHULjvNo2eambTmFQgzw1yVN5p0CqUZ4a5fXps6mm3ZTO_mRHW_3-YtrrYHThG12ZPPzCuGRCDnduRm4o00Vfl7uv8K9XvgHywY3P</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16050940</pqid></control><display><type>article</type><title>Memory B and T Cells</title><source>Annual Reviews</source><source>MEDLINE</source><creator>Vitetta, E S ; Berton, M T ; Burger, C ; Kepron, M ; Lee, W T ; Yin, X M</creator><creatorcontrib>Vitetta, E S ; Berton, M T ; Burger, C ; Kepron, M ; Lee, W T ; Yin, X M</creatorcontrib><description>Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs upregulation of adhesion molecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response.</description><identifier>ISSN: 0732-0582</identifier><identifier>EISSN: 1545-3278</identifier><identifier>DOI: 10.1146/annurev.iy.09.040191.001205</identifier><identifier>PMID: 1910676</identifier><identifier>CODEN: ARIMDU</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Analysis of the immune response. Humoral and cellular immunity ; Animals ; Antibody Affinity ; Antigens, Differentiation ; B-Lymphocytes - immunology ; Biological and medical sciences ; Cell Survival ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Immunologic Memory ; Organs and cells involved in the immune response ; T-Lymphocytes - immunology</subject><ispartof>Annual review of immunology, 1991-01, Vol.9 (1), p.193-217</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a434t-c63a8f3f9ed4629c6dd88f6c4e8a1df018fb0c2067289e5c1e3f9448d65fbd9e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.iy.09.040191.001205?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.iy.09.040191.001205$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,315,781,785,4183,27926,27927,78256,78257</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19694895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1910676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vitetta, E S</creatorcontrib><creatorcontrib>Berton, M T</creatorcontrib><creatorcontrib>Burger, C</creatorcontrib><creatorcontrib>Kepron, M</creatorcontrib><creatorcontrib>Lee, W T</creatorcontrib><creatorcontrib>Yin, X M</creatorcontrib><title>Memory B and T Cells</title><title>Annual review of immunology</title><addtitle>Annu Rev Immunol</addtitle><description>Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs upregulation of adhesion molecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antibody Affinity</subject><subject>Antigens, Differentiation</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Survival</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Immunologic Memory</subject><subject>Organs and cells involved in the immune response</subject><subject>T-Lymphocytes - immunology</subject><issn>0732-0582</issn><issn>1545-3278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkElLxEAQRhtRxnH05lUIiN4Sq5d0uvGiDm4w4mU8Nz29QCTLmJ4o-fcmJKA38VSHel99xUPoHEOCMeNXuqraxn0meZeATIABljgBwATSPTTHKUtjSjKxj-aQURJDKsghOgrhHQAkpdkMzfoE8IzP0emLK-umi-4iXdloHS1dUYRjdOB1EdzJNBfo7eF-vXyKV6-Pz8vbVawZZbvYcKqFp146yziRhlsrhOeGOaGx9YCF34AhfRER0qUGu55lTFie-o2Vji7Q5Xh329QfrQs7VebB9B_oytVtUBnBmGcY_gQxhxQkG8DrETRNHULjvNo2eambTmFQgzw1yVN5p0CqUZ4a5fXps6mm3ZTO_mRHW_3-YtrrYHThG12ZPPzCuGRCDnduRm4o00Vfl7uv8K9XvgHywY3P</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>Vitetta, E S</creator><creator>Berton, M T</creator><creator>Burger, C</creator><creator>Kepron, M</creator><creator>Lee, W T</creator><creator>Yin, X M</creator><general>Annual Reviews</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19910101</creationdate><title>Memory B and T Cells</title><author>Vitetta, E S ; Berton, M T ; Burger, C ; Kepron, M ; Lee, W T ; Yin, X M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a434t-c63a8f3f9ed4629c6dd88f6c4e8a1df018fb0c2067289e5c1e3f9448d65fbd9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Antibody Affinity</topic><topic>Antigens, Differentiation</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell Survival</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Immunologic Memory</topic><topic>Organs and cells involved in the immune response</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vitetta, E S</creatorcontrib><creatorcontrib>Berton, M T</creatorcontrib><creatorcontrib>Burger, C</creatorcontrib><creatorcontrib>Kepron, M</creatorcontrib><creatorcontrib>Lee, W T</creatorcontrib><creatorcontrib>Yin, X M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vitetta, E S</au><au>Berton, M T</au><au>Burger, C</au><au>Kepron, M</au><au>Lee, W T</au><au>Yin, X M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Memory B and T Cells</atitle><jtitle>Annual review of immunology</jtitle><addtitle>Annu Rev Immunol</addtitle><date>1991-01-01</date><risdate>1991</risdate><volume>9</volume><issue>1</issue><spage>193</spage><epage>217</epage><pages>193-217</pages><issn>0732-0582</issn><eissn>1545-3278</eissn><coden>ARIMDU</coden><abstract>Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs upregulation of adhesion molecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>1910676</pmid><doi>10.1146/annurev.iy.09.040191.001205</doi><tpages>25</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-0582 |
| ispartof | Annual review of immunology, 1991-01, Vol.9 (1), p.193-217 |
| issn | 0732-0582 1545-3278 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72116710 |
| source | Annual Reviews; MEDLINE |
| subjects | Analysis of the immune response. Humoral and cellular immunity Animals Antibody Affinity Antigens, Differentiation B-Lymphocytes - immunology Biological and medical sciences Cell Survival Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunologic Memory Organs and cells involved in the immune response T-Lymphocytes - immunology |
| title | Memory B and T Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T00%3A36%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_annua&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Memory%20B%20and%20T%20Cells&rft.jtitle=Annual%20review%20of%20immunology&rft.au=Vitetta,%20E%20S&rft.date=1991-01-01&rft.volume=9&rft.issue=1&rft.spage=193&rft.epage=217&rft.pages=193-217&rft.issn=0732-0582&rft.eissn=1545-3278&rft.coden=ARIMDU&rft_id=info:doi/10.1146/annurev.iy.09.040191.001205&rft_dat=%3Cproquest_annua%3E16050940%3C/proquest_annua%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16050940&rft_id=info:pmid/1910676&rfr_iscdi=true |