Convenient synthesis and evaluation of enzyme inhibitory activity of several N-alkyl-, N-phenylalkyl, and cyclic isourea derivatives of 5a-carba-α-DL-fucopyranosylamine

Convenient synthesis and chemical modification of the potent alpha-L-fucosidase inhibitor, 5a-carba-alpha-DL-fucopyranosylamine (1), are described. Among seven N-substituted and three cyclic isourea derivatives newly prepared, the N-octyl derivative was found to be the strongest inhibitor of alpha-L...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-10, Vol.12 (20), p.2811-2814
Hauptverfasser:	OGAWA, Seiichiro, MORI, Makiko, TAKEUCHI, Goichi, DOI, Fuminao, WATANABE, Maiko, SAKATA, Yuko
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-L-Fucosidase - antagonists & inhibitors Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cattle Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Enzymes and enzyme inhibitors Fucose - analogs & derivatives Fucose - chemical synthesis Fucose - pharmacology Fundamental and applied biological sciences. Psychology Glycoside Hydrolases - antagonists & inhibitors Hydrolases Indicators and Reagents Kidney - drug effects Medical sciences Miscellaneous Molecular Conformation Pharmacology. Drug treatments Structure-Activity Relationship
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