The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: A preliminary study
The effects of exogenous, supraphysiologic doses of melatonin on the total sleep time and daytime alertness of patients with chronic insomnia was examined in a double blind, single crossover study. Melatonin (75 mg per os) or identical placebo was administered at 10 pm daily to 13 insomniac patients...
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| Veröffentlicht in: | Biological psychiatry (1969) 1991-08, Vol.30 (4), p.371-376 |
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| container_end_page | 376 |
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| container_issue | 4 |
| container_start_page | 371 |
| container_title | Biological psychiatry (1969) |
| container_volume | 30 |
| creator | MacFarlane, James G. Cleghorn, John M. Brown, Gregory M. Streiner, David L. |
| description | The effects of exogenous, supraphysiologic doses of melatonin on the total sleep time and daytime alertness of patients with chronic insomnia was examined in a double blind, single crossover study. Melatonin (75 mg per os) or identical placebo was administered at 10
pm daily to 13 insomniac patients for 14 consecutive days. A significant increase in the subjective assessment of total sleep time and daytime alertness was demonstrated with melatonin but not with placebo. However, 7 of the 13 patients reported that the active treatment had no significant effect on subjective feelings of well-being. |
| doi_str_mv | 10.1016/0006-3223(91)90293-U |
| format | Article |
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pm daily to 13 insomniac patients for 14 consecutive days. A significant increase in the subjective assessment of total sleep time and daytime alertness was demonstrated with melatonin but not with placebo. However, 7 of the 13 patients reported that the active treatment had no significant effect on subjective feelings of well-being.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Circadian Rhythm - drug effects</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melatonin - pharmacokinetics</subject><subject>Melatonin - therapeutic use</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Single-Blind Method</subject><subject>Sleep - drug effects</subject><subject>Sleep Initiation and Maintenance Disorders - drug therapy</subject><subject>Wakefulness - drug effects</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo6-zqP1DIQUQPranqbw_CsvgFC152ziGdVLuRdDImmcXBP29me1hv5pIU9bwvVW8YewHiHQjo3gshuqpGrN-M8HYUONbV9hHbwNDXFTYCH7PNA_KUnaf0s5Q9IpyxMxgBAYcN-3NzS5zmmXROPMycfocf5MM-8YWcysFbz4PnuVA5ZOV4ckQ7nu1CXHnDjTqsb0cxe0r3Jvo2FqHm1qeweKt0-sAv-S6Ss4v1Kh54yntzeMaezMolen66L9j286ebq6_V9fcv364urytdD12uaJgUCm3QiLElmod20r3qOjACJoNt0-uypjCdbmo9IjXDTNgOXTO1Iwlo6gv2evXdxfBrTynLxSZNzilPZVPZI0BbTgGbFdQxpBRplrtolzKvBCGPmctjoPIYqBxB3mcut0X28uS_nxYy_0RryKX_6tRXSSs3R-W1TQ9YCwNCiwX7uGJUsrizFGXSlrwmY2P5HmmC_f8cfwEZGp7R</recordid><startdate>19910815</startdate><enddate>19910815</enddate><creator>MacFarlane, James G.</creator><creator>Cleghorn, John M.</creator><creator>Brown, Gregory M.</creator><creator>Streiner, David L.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910815</creationdate><title>The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: A preliminary study</title><author>MacFarlane, James G. ; Cleghorn, John M. ; Brown, Gregory M. ; Streiner, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-e8ba20cd2d095eef85bc7a661d01bd2547c0060d6c43c92e48fe25864b59e0143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Circadian Rhythm - drug effects</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Hormones. 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| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 1991-08, Vol.30 (4), p.371-376 |
| issn | 0006-3223 1873-2402 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Administration, Oral Adult Aged Biological and medical sciences Chronic Disease Circadian Rhythm - drug effects Double-Blind Method Female Hormones. Endocrine system Humans Male Medical sciences Melatonin - pharmacokinetics Melatonin - therapeutic use Middle Aged Multivariate Analysis Pharmacology. Drug treatments Single-Blind Method Sleep - drug effects Sleep Initiation and Maintenance Disorders - drug therapy Wakefulness - drug effects |
| title | The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: A preliminary study |
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