Inhibition of a plant sesquiterpene cyclase by mevinolin

The specificity of mevinolin as an inhibitor of sterol and sesquiterpene metabolism in tobacco cell suspension cultures was examined. Exogenous mevinolin inhibited [ 14C]acetate, but not [ 3H]mevalonate incorporation into free sterols. In contrast, mevinolin inhibited the incorporation of both [ 14C...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1991-07, Vol.288 (1), p.157-162
Hauptverfasser:	Vögeli, Urs, Chappell, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - metabolism Acetic Acid Analytical, structural and metabolic biochemistry Biological and medical sciences BIOSINTESIS BIOSYNTHESE CULTIVO DE CELULAS CULTURE DE CELLULE Fundamental and applied biological sciences. Psychology Hydroxymethylglutaryl-CoA Reductase Inhibitors INHIBICION INHIBITION Intramolecular Lyases Isomerases - antagonists & inhibitors Kinetics Lovastatin - pharmacology Mevalonic Acid - metabolism NICOTIANA TABACUM Other biological molecules Plants - metabolism sesquiterpene cyclase Sesquiterpenes - metabolism SESQUITERPENOIDE SESQUITERPENOS Terpenes, steroids. Hormones
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