Thrombospondin binds normally to glycoprotein IIIb deficient platelets

Glycoprotein IIIb (GPIV, CD36) has been proposed as the platelet receptor for thrombospondin (TSP). We found two healthy blood donors, whose platelets were shown to be GPIIIb deficient. These platelets expressed endogeneous TSP as control platelets and their binding capacity for exogeneous TSP was t...

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Veröffentlicht in:	Biochemical and biophysical research communications 1991-09, Vol.179 (2), p.985-991
Hauptverfasser:	Kehrel, Beate, Kronenberg, Antje, Schwippert, Barbara, Niesing-Bresch, Doris, Niehues, Ulrike, Tschöpe, Diethelm, van de Loo, Jürgen, Clemetson, Kenneth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal Antigens, CD - deficiency Antigens, CD - metabolism Biological and medical sciences Blood Platelets - metabolism CD36 Antigens Cell receptors Cell structures and functions Flow Cytometry Fundamental and applied biological sciences. Psychology glycoprotein IIIb Humans Immunoblotting Male Miscellaneous Molecular and cellular biology Platelet Membrane Glycoproteins - metabolism thrombospondin Thrombospondins
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