Regulation of mucosal dendritic cell function by receptor activator of NF-kappa B (RANK)/RANK ligand interactions: impact on tolerance induction

The mucosal immune system is uniquely equipped to discriminate between potentially invasive pathogens and innocuous food proteins. While the mechanisms responsible for induction of mucosal immunity vs tolerance are not yet fully delineated, recent studies have highlighted mucosal dendritic cells (DC...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-10, Vol.169 (7), p.3606-3612
Hauptverfasser:	Williamson, Eilidh, Bilsborough, Janine M, Viney, Joanne L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - physiology Administration, Oral Adoptive Transfer Animals Carrier Proteins - administration & dosage Carrier Proteins - metabolism Carrier Proteins - physiology Cell Separation Cells, Cultured Dendritic Cells - immunology Dendritic Cells - metabolism Female Glycoproteins - biosynthesis Glycoproteins - metabolism Glycoproteins - physiology Immune Tolerance - immunology Immunity, Mucosal - immunology Injections, Intraperitoneal Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Ligands Lymph Nodes - immunology Lymph Nodes - metabolism Membrane Glycoproteins - administration & dosage Membrane Glycoproteins - metabolism Membrane Glycoproteins - physiology Mesentery Mice Mice, Inbred BALB C Mice, Transgenic Models, Immunological NF-kappa B - metabolism Osteoprotegerin Ovalbumin - administration & dosage Ovalbumin - immunology Peyer's Patches - cytology Peyer's Patches - immunology Peyer's Patches - metabolism RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Cytoplasmic and Nuclear - physiology Receptors, Tumor Necrosis Factor Spleen - cytology Spleen - immunology Spleen - metabolism T-Lymphocyte Subsets - transplantation
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