Notch1 and Jagged1 expression by the developing pulmonary vasculature

The molecular mechanisms of pulmonary vascular development are poorly understood. Cell‐specific developmental pathways are influenced by cell–cell signaling. Notch signaling molecules are highly conserved receptors active in many cell‐fate determination systems. Recent observations of Notch molecule...

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Veröffentlicht in:	Developmental dynamics 2002-10, Vol.225 (2), p.166-175
Hauptverfasser:	Taichman, Darren B., Loomes, Kathleen M., Schachtner, Susan K., Guttentag, Susan, Vu, Colynda, Williams, Patrick, Oakey, Rebecca J., Baldwin, H. Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - embryology Calcium-Binding Proteins Cell Membrane - metabolism development endothelial Endothelium, Vascular - embryology Immunohistochemistry In Situ Hybridization Intercellular Signaling Peptides and Proteins Jagged Jagged-1 Protein Kidney - embryology lung Lung - blood supply Lung - embryology Membrane Proteins - biosynthesis Membrane Proteins - metabolism Mice Microscopy, Electron Microscopy, Fluorescence Notch PECAM Protein Biosynthesis Proteins pulmonary Receptor, Notch1 Receptors, Cell Surface Receptors, Notch Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Serrate-Jagged Proteins Signal Transduction Time Factors Transcription Factors vascular vasculogenesis
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