Effects of long-term denervation on skeletal muscle in old rats

We compared the reactions to denervation of limb muscles between young adult and old rats. After denervation for up to 4 months in 24-month-old rats, limb muscles were removed and analyzed for contractile properties, morphology, and levels of several key molecules, including the peptide elongation f...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2002-10, Vol.57 (10), p.B366-B374
Hauptverfasser:	Carlson, Bruce M, Borisov, Andrei B, Dedkov, Eduard I, Khalyfa, Abdelnaby, Kostrominova, Tatiana Y, Macpherson, Peter C D, Wang, Eugenia, Faulkner, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Animals Biomarkers - blood Cyclin D3 Cyclins - metabolism Male Models, Animal Muscle Contraction - physiology Muscle Denervation Muscle Fibers, Skeletal - physiology Muscle, Skeletal - innervation Muscle, Skeletal - physiology Muscular system Myogenin - metabolism Nervous system Peptide Elongation Factor 1 - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Rodents Time Treatment Outcome
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