Effect of fluoxetine on noradrenergic mediated growth hormone release: A double blind, placebo-controlled study
Twelve patients with DSM-III-R major depressive illness were tested for growth hormone (GH) response to desipramine (DMI), a noradrenergic (NA) reuptake inhibitor. The response is mediated by NA α 2 receptors. They were then randomly assigned to treatment under double-blind conditions with either fl...
Gespeichert in:
| Veröffentlicht in: | Biological psychiatry (1969) 1991-08, Vol.30 (4), p.377-382 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 382 |
|---|---|
| container_issue | 4 |
| container_start_page | 377 |
| container_title | Biological psychiatry (1969) |
| container_volume | 30 |
| creator | O'Flynn, Karen O'Keane, Veronica Lucey, James V. Dinan, Timothy G. |
| description | Twelve patients with DSM-III-R major depressive illness were tested for growth hormone (GH) response to desipramine (DMI), a noradrenergic (NA) reuptake inhibitor. The response is mediated by NA α
2 receptors. They were then randomly assigned to treatment under double-blind conditions with either fluoxetine, the highly selective serotonin reuptake inhibitor or placebo. After 4 weeks they were retested. Fluoxetine but not placebo was effective in promoting recovery in four of the six patients treated. Patients treated with fluoxetine showed a significant decrease in DMI-mediated GH release irrespective of therapeutic outcome. This is consistent with marked alteration of NA function and raises questions as to the selectivity of fluoxetine. |
| doi_str_mv | 10.1016/0006-3223(91)90294-V |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72111462</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>000632239190294V</els_id><sourcerecordid>72111462</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-8357dfbe47219e4bf1af327c525af75b577d08289e89a298c7bbe75243be39d33</originalsourceid><addsrcrecordid>eNp9kU1LXDEUhoNU7NT6D1rIQkoL3jYf905uuiiIWBWEblq3IR8nmpJJxuTetv57M86gu65COM_7cngOQu8o-UwJXX4hhCw7zhj_KOknSZjsu5s9tKCj4B3rCXuFFs_Ia_Sm1t_tKxijB-iASsookwuUz70HO-HssY9z_gdTSIBzwikX7QokKLfB4hW4oCdw-Lbkv9MdvstllRtYIIKu8BWfYpdnEwGbGJI7weuoLZjc2ZymkmNs0TrN7uEt2vc6VjjavYfo1_fzn2eX3fWPi6uz0-vO8nE5dSMfhPMGesGohN54qj1nwg5s0F4MZhDCkZGNEkapmRytMAbEwHpugEvH-SH6sO1dl3w_Q53UKlQLMeoEea6q9VLaL1kD-y1oS661gFfrEla6PChK1Maz2khUG4lKUvXkWd202Ptd_2yanJfQVmybH-_mulodfdHJhvqMDXRkdNis-W2LQXPxJ0BR1QZItuku7SzK5fD_PR4BdaKaUQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72111462</pqid></control><display><type>article</type><title>Effect of fluoxetine on noradrenergic mediated growth hormone release: A double blind, placebo-controlled study</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>O'Flynn, Karen ; O'Keane, Veronica ; Lucey, James V. ; Dinan, Timothy G.</creator><creatorcontrib>O'Flynn, Karen ; O'Keane, Veronica ; Lucey, James V. ; Dinan, Timothy G.</creatorcontrib><description>Twelve patients with DSM-III-R major depressive illness were tested for growth hormone (GH) response to desipramine (DMI), a noradrenergic (NA) reuptake inhibitor. The response is mediated by NA α
2 receptors. They were then randomly assigned to treatment under double-blind conditions with either fluoxetine, the highly selective serotonin reuptake inhibitor or placebo. After 4 weeks they were retested. Fluoxetine but not placebo was effective in promoting recovery in four of the six patients treated. Patients treated with fluoxetine showed a significant decrease in DMI-mediated GH release irrespective of therapeutic outcome. This is consistent with marked alteration of NA function and raises questions as to the selectivity of fluoxetine.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/0006-3223(91)90294-V</identifier><identifier>PMID: 1912129</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Analysis of Variance ; Biological and medical sciences ; Depressive Disorder - drug therapy ; Depressive Disorder - metabolism ; Depressive Disorder - psychology ; Desipramine - pharmacology ; Double-Blind Method ; Female ; Fluoxetine - pharmacology ; Fluoxetine - therapeutic use ; Growth Hormone - blood ; Growth Hormone - metabolism ; Humans ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Norepinephrine - physiology ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology</subject><ispartof>Biological psychiatry (1969), 1991-08, Vol.30 (4), p.377-382</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-8357dfbe47219e4bf1af327c525af75b577d08289e89a298c7bbe75243be39d33</citedby><cites>FETCH-LOGICAL-c386t-8357dfbe47219e4bf1af327c525af75b577d08289e89a298c7bbe75243be39d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-3223(91)90294-V$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27925,27926,45996</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5182153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1912129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Flynn, Karen</creatorcontrib><creatorcontrib>O'Keane, Veronica</creatorcontrib><creatorcontrib>Lucey, James V.</creatorcontrib><creatorcontrib>Dinan, Timothy G.</creatorcontrib><title>Effect of fluoxetine on noradrenergic mediated growth hormone release: A double blind, placebo-controlled study</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Twelve patients with DSM-III-R major depressive illness were tested for growth hormone (GH) response to desipramine (DMI), a noradrenergic (NA) reuptake inhibitor. The response is mediated by NA α
2 receptors. They were then randomly assigned to treatment under double-blind conditions with either fluoxetine, the highly selective serotonin reuptake inhibitor or placebo. After 4 weeks they were retested. Fluoxetine but not placebo was effective in promoting recovery in four of the six patients treated. Patients treated with fluoxetine showed a significant decrease in DMI-mediated GH release irrespective of therapeutic outcome. This is consistent with marked alteration of NA function and raises questions as to the selectivity of fluoxetine.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - metabolism</subject><subject>Depressive Disorder - psychology</subject><subject>Desipramine - pharmacology</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fluoxetine - pharmacology</subject><subject>Fluoxetine - therapeutic use</subject><subject>Growth Hormone - blood</subject><subject>Growth Hormone - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Norepinephrine - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LXDEUhoNU7NT6D1rIQkoL3jYf905uuiiIWBWEblq3IR8nmpJJxuTetv57M86gu65COM_7cngOQu8o-UwJXX4hhCw7zhj_KOknSZjsu5s9tKCj4B3rCXuFFs_Ia_Sm1t_tKxijB-iASsookwuUz70HO-HssY9z_gdTSIBzwikX7QokKLfB4hW4oCdw-Lbkv9MdvstllRtYIIKu8BWfYpdnEwGbGJI7weuoLZjc2ZymkmNs0TrN7uEt2vc6VjjavYfo1_fzn2eX3fWPi6uz0-vO8nE5dSMfhPMGesGohN54qj1nwg5s0F4MZhDCkZGNEkapmRytMAbEwHpugEvH-SH6sO1dl3w_Q53UKlQLMeoEea6q9VLaL1kD-y1oS661gFfrEla6PChK1Maz2khUG4lKUvXkWd202Ptd_2yanJfQVmybH-_mulodfdHJhvqMDXRkdNis-W2LQXPxJ0BR1QZItuku7SzK5fD_PR4BdaKaUQ</recordid><startdate>19910815</startdate><enddate>19910815</enddate><creator>O'Flynn, Karen</creator><creator>O'Keane, Veronica</creator><creator>Lucey, James V.</creator><creator>Dinan, Timothy G.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910815</creationdate><title>Effect of fluoxetine on noradrenergic mediated growth hormone release: A double blind, placebo-controlled study</title><author>O'Flynn, Karen ; O'Keane, Veronica ; Lucey, James V. ; Dinan, Timothy G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-8357dfbe47219e4bf1af327c525af75b577d08289e89a298c7bbe75243be39d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - metabolism</topic><topic>Depressive Disorder - psychology</topic><topic>Desipramine - pharmacology</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fluoxetine - pharmacology</topic><topic>Fluoxetine - therapeutic use</topic><topic>Growth Hormone - blood</topic><topic>Growth Hormone - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Norepinephrine - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Flynn, Karen</creatorcontrib><creatorcontrib>O'Keane, Veronica</creatorcontrib><creatorcontrib>Lucey, James V.</creatorcontrib><creatorcontrib>Dinan, Timothy G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Flynn, Karen</au><au>O'Keane, Veronica</au><au>Lucey, James V.</au><au>Dinan, Timothy G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of fluoxetine on noradrenergic mediated growth hormone release: A double blind, placebo-controlled study</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1991-08-15</date><risdate>1991</risdate><volume>30</volume><issue>4</issue><spage>377</spage><epage>382</epage><pages>377-382</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Twelve patients with DSM-III-R major depressive illness were tested for growth hormone (GH) response to desipramine (DMI), a noradrenergic (NA) reuptake inhibitor. The response is mediated by NA α
2 receptors. They were then randomly assigned to treatment under double-blind conditions with either fluoxetine, the highly selective serotonin reuptake inhibitor or placebo. After 4 weeks they were retested. Fluoxetine but not placebo was effective in promoting recovery in four of the six patients treated. Patients treated with fluoxetine showed a significant decrease in DMI-mediated GH release irrespective of therapeutic outcome. This is consistent with marked alteration of NA function and raises questions as to the selectivity of fluoxetine.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1912129</pmid><doi>10.1016/0006-3223(91)90294-V</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 1991-08, Vol.30 (4), p.377-382 |
| issn | 0006-3223 1873-2402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72111462 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Analysis of Variance Biological and medical sciences Depressive Disorder - drug therapy Depressive Disorder - metabolism Depressive Disorder - psychology Desipramine - pharmacology Double-Blind Method Female Fluoxetine - pharmacology Fluoxetine - therapeutic use Growth Hormone - blood Growth Hormone - metabolism Humans Male Medical sciences Middle Aged Neuropharmacology Norepinephrine - physiology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology |
| title | Effect of fluoxetine on noradrenergic mediated growth hormone release: A double blind, placebo-controlled study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T14%3A10%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20fluoxetine%20on%20noradrenergic%20mediated%20growth%20hormone%20release:%20A%20double%20blind,%20placebo-controlled%20study&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=O'Flynn,%20Karen&rft.date=1991-08-15&rft.volume=30&rft.issue=4&rft.spage=377&rft.epage=382&rft.pages=377-382&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/0006-3223(91)90294-V&rft_dat=%3Cproquest_cross%3E72111462%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72111462&rft_id=info:pmid/1912129&rft_els_id=000632239190294V&rfr_iscdi=true |