Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins from Trypanosoma cruzi Bind to CD1d but Do Not Elicit Dominant Innate or Adaptive Immune Responses Via the CD1d/NKT Cell Pathway

It has been proposed that self and protozoan-derived GPI anchors are natural ligands of CD1d. In this study, we investigated the ability of GPI anchors from Trypanosoma cruzi to bind to CD1d and mediate activation of NKT cells. We observed that GPI-anchored mucin-like glycoproteins (GPI mucins), gly...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-10, Vol.169 (7), p.3926-3933
Hauptverfasser:	Procopio, Daniela O, Almeida, Igor C, Torrecilhas, Ana Claudia T, Cardoso, Jarbas E, Teyton, Luc, Travassos, Luiz R, Bendelac, Albert, Gazzinelli, Ricardo T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Protozoan - biosynthesis Antibodies, Protozoan - blood Antigens, CD1 - biosynthesis Antigens, CD1 - genetics Antigens, CD1 - metabolism Antigens, CD1 - physiology Antigens, CD1d Binding, Competitive - immunology Carbohydrate Sequence Cells, Cultured Chagas Disease - genetics Chagas Disease - immunology Cytokines - biosynthesis Female Genetic Predisposition to Disease Glycoproteins - metabolism Glycoproteins - physiology Glycosylphosphatidylinositols - administration & dosage Glycosylphosphatidylinositols - chemistry Glycosylphosphatidylinositols - metabolism Glycosylphosphatidylinositols - physiology Immunity, Innate - genetics Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - parasitology Macrophage Activation - genetics Macrophage Activation - immunology Male Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Mucins - administration & dosage Mucins - chemistry Mucins - metabolism Mucins - physiology Protozoan Proteins - immunology Protozoan Proteins - metabolism Signal Transduction - genetics Signal Transduction - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - parasitology Trypanosoma cruzi - chemistry Trypanosoma cruzi - immunology Trypanosoma cruzi - metabolism
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