Synthesis of Novel 4,1-Benzoxazepine Derivatives as Squalene Synthase Inhibitors and Their Inhibition of Cholesterol Synthesis

Modification of the carboxyl group at the 3-position and introduction of protective groups to the hydroxy group of the 4,1-benzoxazepine derivative 2 (metabolite of 1) were carried out, and the inhibitory activity for squalene synthase and cholesterol synthesis in the liver was investigated. Among t...

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Veröffentlicht in:Journal of medicinal chemistry 2002-09, Vol.45 (20), p.4571-4580
Hauptverfasser: Miki, Takashi, Kori, Masakuni, Mabuchi, Hiroshi, Tozawa, Ryu-ichi, Nishimoto, Tomoyuki, Sugiyama, Yasuo, Teshima, Koichiro, Yukimasa, Hidefumi
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Sprache:eng
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