Oleate and Linoleate Enhance the Growth-promoting Effects of Insulin-like Growth Factor-I through a Phospholipase D-dependent Pathway in Arterial Smooth Muscle Cells

Diabetes causes accelerated atherosclerosis and subsequent cardiovascular disease through mechanisms that are poorly understood. We have previously shown, using a porcine model of diabetes-accelerated atherosclerosis, that diabetes leads to an increased accumulation and proliferation of arterial smo...

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Veröffentlicht in:	The Journal of biological chemistry 2002-09, Vol.277 (39), p.36338-36344
Hauptverfasser:	Askari, Bardia, Carroll, Mairead A., Capparelli, Maria, Kramer, Farah, Gerrity, Ross G., Bornfeldt, Karin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries - cytology Cell Division Cell Membrane - metabolism Diabetes Mellitus, Experimental DNA - biosynthesis DNA - metabolism Endothelium, Vascular - cytology Immunohistochemistry Insulin-Like Growth Factor I - metabolism Linoleic Acid - pharmacology Linoleic Acids - metabolism Lipid Metabolism Models, Biological Muscle, Smooth - cytology Oleic Acid - pharmacology Phospholipase D - metabolism Phosphorylation Swine Thymidine - metabolism Time Factors Triglycerides - metabolism
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