Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata
Abstract Suspensions of rat peritoneal polymorphonuclear leukocytes (PMNL) elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic acid (AA). We investigated the effect of ethanolic extracts of the gum resin exudate of BOSWELLIA...
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Veröffentlicht in: | Planta medica 1991-06, Vol.57 (3), p.203-207 |
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description | Abstract
Suspensions of rat peritoneal polymorphonuclear leukocytes (PMNL) elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic acid (AA). We investigated the effect of ethanolic extracts of the gum resin exudate of BOSWELLIA SERRATA. A concentration-dependent inhibition of LTB
4
and 5-HETE production by different charges of exudate extracts were found. All products of the 5-lipoxygenase (5-LOx) from endogenous arachidonic acid (AA) in PMNL were reduced to the same extent by the extracts tested. The ethanolic extract of the gum resin also decreased 5-LOx mediated metabolisation of exogenously added AA to LTB
4
and 5-HETE. Since steroidal-type anti-inflammatory drugs do not exert an immediate effect in the test system used, we conclude that the activity of the 5-LOx itself represents the side of inhibition by the gum resin extract. Therefore, an inhibition of 5-LOx catalysed mediator synthesis might be involved in the previously reported anti-inflammatory activity IN VIVO. |
doi_str_mv | 10.1055/s-2006-960074 |
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Suspensions of rat peritoneal polymorphonuclear leukocytes (PMNL) elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic acid (AA). We investigated the effect of ethanolic extracts of the gum resin exudate of BOSWELLIA SERRATA. A concentration-dependent inhibition of LTB
4
and 5-HETE production by different charges of exudate extracts were found. All products of the 5-lipoxygenase (5-LOx) from endogenous arachidonic acid (AA) in PMNL were reduced to the same extent by the extracts tested. The ethanolic extract of the gum resin also decreased 5-LOx mediated metabolisation of exogenously added AA to LTB
4
and 5-HETE. Since steroidal-type anti-inflammatory drugs do not exert an immediate effect in the test system used, we conclude that the activity of the 5-LOx itself represents the side of inhibition by the gum resin extract. Therefore, an inhibition of 5-LOx catalysed mediator synthesis might be involved in the previously reported anti-inflammatory activity IN VIVO.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-960074</identifier><identifier>PMID: 1654575</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; anti-inflammatory agents ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Biological and medical sciences ; Boswellia serrata ; Cells, Cultured ; drugs ; General pharmacology ; inhibition ; Leukotriene B4 - biosynthesis ; Lipoxygenase Inhibitors ; Medical sciences ; neutrophils ; Neutrophils - drug effects ; Neutrophils - metabolism ; Peritoneal Cavity - cytology ; peritoneum ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - pharmacology ; Rats ; Rats, Inbred Strains ; Resins, Plant ; Triterpenes - pharmacology</subject><ispartof>Planta medica, 1991-06, Vol.57 (3), p.203-207</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-960074.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,776,780,3005,27901,27902,54534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19672386$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1654575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ammon, H.P.T</creatorcontrib><creatorcontrib>Mack, T</creatorcontrib><creatorcontrib>Singh, G.B</creatorcontrib><creatorcontrib>Safayhi, H</creatorcontrib><title>Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
Suspensions of rat peritoneal polymorphonuclear leukocytes (PMNL) elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic acid (AA). We investigated the effect of ethanolic extracts of the gum resin exudate of BOSWELLIA SERRATA. A concentration-dependent inhibition of LTB
4
and 5-HETE production by different charges of exudate extracts were found. All products of the 5-lipoxygenase (5-LOx) from endogenous arachidonic acid (AA) in PMNL were reduced to the same extent by the extracts tested. The ethanolic extract of the gum resin also decreased 5-LOx mediated metabolisation of exogenously added AA to LTB
4
and 5-HETE. Since steroidal-type anti-inflammatory drugs do not exert an immediate effect in the test system used, we conclude that the activity of the 5-LOx itself represents the side of inhibition by the gum resin extract. Therefore, an inhibition of 5-LOx catalysed mediator synthesis might be involved in the previously reported anti-inflammatory activity IN VIVO.</description><subject>Animals</subject><subject>anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Boswellia serrata</subject><subject>Cells, Cultured</subject><subject>drugs</subject><subject>General pharmacology</subject><subject>inhibition</subject><subject>Leukotriene B4 - biosynthesis</subject><subject>Lipoxygenase Inhibitors</subject><subject>Medical sciences</subject><subject>neutrophils</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Peritoneal Cavity - cytology</subject><subject>peritoneum</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Resins, Plant</subject><subject>Triterpenes - pharmacology</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EKkvhyBHhC5wIjB1_xEda8VGpEgfo2XKSceOS2IvtiPYv8KvJsitxmsP76NHMvIS8ZPCegZQfSsMBVGMUgBaPyI6J1jTAOXtMdgAtb8CI9il5VsodABMG4IycMSWF1HJH_lzFKfShhhRp8nTG9WeqOWBEeiGoT3lx_7IQaXaV7jGHmiK6mUZca077KcyF9g_URYp1cjHNYaB4X7Mb6sFYJ6S360Izls2B9-voKh6Ci1R-4zwHRwvmze2ekyfezQVfnOY5ufn86cfl1-b625ery4_XjedG10aYvjNaG9mjFOA7KQwzSvSsFYMalVe97JR2hvtu9Mi7AXunJJMd6_nIvGjPydujd5_TrxVLtUsow7aKi5jWYjVnYDSDDXx1Atd-wdHuc1hcfrCn5235m1PuyuBmn10cQvmPGaV526mNe3fk6hRwQXuX1hy3Cy0De6jQFnuo0B4r3PDXR9y7ZN1t3pQ33zmwFphWjBnW_gUARZY7</recordid><startdate>19910601</startdate><enddate>19910601</enddate><creator>Ammon, H.P.T</creator><creator>Mack, T</creator><creator>Singh, G.B</creator><creator>Safayhi, H</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19910601</creationdate><title>Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata</title><author>Ammon, H.P.T ; Mack, T ; Singh, G.B ; Safayhi, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f297t-49b897795be540f85491964b134c6d6f6b5867a92f8dfe28ceba651581b2d1f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Boswellia serrata</topic><topic>Cells, Cultured</topic><topic>drugs</topic><topic>General pharmacology</topic><topic>inhibition</topic><topic>Leukotriene B4 - biosynthesis</topic><topic>Lipoxygenase Inhibitors</topic><topic>Medical sciences</topic><topic>neutrophils</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>Peritoneal Cavity - cytology</topic><topic>peritoneum</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Resins, Plant</topic><topic>Triterpenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ammon, H.P.T</creatorcontrib><creatorcontrib>Mack, T</creatorcontrib><creatorcontrib>Singh, G.B</creatorcontrib><creatorcontrib>Safayhi, H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ammon, H.P.T</au><au>Mack, T</au><au>Singh, G.B</au><au>Safayhi, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1991-06-01</date><risdate>1991</risdate><volume>57</volume><issue>3</issue><spage>203</spage><epage>207</epage><pages>203-207</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
Suspensions of rat peritoneal polymorphonuclear leukocytes (PMNL) elicited with glycogen were stimulated by calcium and ionophore to produce leukotrienes and 5-HETE from endogenous arachidonic acid (AA). We investigated the effect of ethanolic extracts of the gum resin exudate of BOSWELLIA SERRATA. A concentration-dependent inhibition of LTB
4
and 5-HETE production by different charges of exudate extracts were found. All products of the 5-lipoxygenase (5-LOx) from endogenous arachidonic acid (AA) in PMNL were reduced to the same extent by the extracts tested. The ethanolic extract of the gum resin also decreased 5-LOx mediated metabolisation of exogenously added AA to LTB
4
and 5-HETE. Since steroidal-type anti-inflammatory drugs do not exert an immediate effect in the test system used, we conclude that the activity of the 5-LOx itself represents the side of inhibition by the gum resin extract. Therefore, an inhibition of 5-LOx catalysed mediator synthesis might be involved in the previously reported anti-inflammatory activity IN VIVO.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>1654575</pmid><doi>10.1055/s-2006-960074</doi><tpages>5</tpages></addata></record> |
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subjects | Animals anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Boswellia serrata Cells, Cultured drugs General pharmacology inhibition Leukotriene B4 - biosynthesis Lipoxygenase Inhibitors Medical sciences neutrophils Neutrophils - drug effects Neutrophils - metabolism Peritoneal Cavity - cytology peritoneum Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology Rats Rats, Inbred Strains Resins, Plant Triterpenes - pharmacology |
title | Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata |
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