Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer
We present findings on the associations between DNA adduct levels in breast tissue, risk of breast cancer, and polymorphisms in the DNA repair enzyme XPD. Breast cancer cases, benign breast disease (BBD) controls, and healthy controls were enrolled. Polycyclic aromatic hydrocarbons (PAH)-DNA adduct...
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| Veröffentlicht in: | Breast cancer research and treatment 2002-09, Vol.75 (2), p.159-166 |
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| creator | DELIANG TANG STAN CHO RUNDLE, Andrew SENQING CHEN PHILLIPS, David JINGZHI ZHOU YANZHI HSU SCHNABEL, Freya ESTABROOK, Alison PERERA, Frederica P |
| description | We present findings on the associations between DNA adduct levels in breast tissue, risk of breast cancer, and polymorphisms in the DNA repair enzyme XPD. Breast cancer cases, benign breast disease (BBD) controls, and healthy controls were enrolled. Polycyclic aromatic hydrocarbons (PAH)-DNA adduct levels were measured by immunohistochemistry in breast tissue samples from cases and BBD controls. XPD polymorphisms at codons 312 and 751 was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis using white blood cell DNA. Neither of the polymorphisms were associated with case-control status, both in comparisons of cases and BBD controls, and cases and healthy controls. XPD polymorphisms at codons 312 and 751 were associated with higher levels of PAH-DNA in tumor tissue from breast cancer cases. Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s. 0.33 OD, p < 0.01). PAH-DNA adducts were associated with increasing copy number of the Gln allele for the codon 751 polymorphism (p for trend |
| doi_str_mv | 10.1023/A:1019693504183 |
| format | Article |
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Breast cancer cases, benign breast disease (BBD) controls, and healthy controls were enrolled. Polycyclic aromatic hydrocarbons (PAH)-DNA adduct levels were measured by immunohistochemistry in breast tissue samples from cases and BBD controls. XPD polymorphisms at codons 312 and 751 was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis using white blood cell DNA. Neither of the polymorphisms were associated with case-control status, both in comparisons of cases and BBD controls, and cases and healthy controls. XPD polymorphisms at codons 312 and 751 were associated with higher levels of PAH-DNA in tumor tissue from breast cancer cases. Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s. 0.33 OD, p < 0.01). PAH-DNA adducts were associated with increasing copy number of the Gln allele for the codon 751 polymorphism (p for trend <0.01). Among subjects with the Asp/Asn or Asn/Asn genotype at codon 312, adduct levels were higher in tumor tissue compared to tissue from BBD controls (0.55 OD v.s. 0.36 OD, p = 0.003). Among subjects with the Gln/Gln genotype at codon 751 adduct levels were higher in tumor tissue compared to tissue from BBD controls (0.68 OD v.s. 0.40 OD, p = 0.01). The trend of increasing PAH-DNA adduct levels with either the Asn/Asn or Gln/Gln genotype was greater in tumor tissue than the trend in BBD control tissue.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1023/A:1019693504183</identifier><identifier>PMID: 12243508</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Analysis of Variance ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - chemistry ; Breast Neoplasms - genetics ; Cancer research ; Cancer therapies ; Case-Control Studies ; DNA Adducts - analysis ; DNA Helicases ; DNA Repair ; DNA-Binding Proteins ; Female ; Genotype ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Polycyclic Aromatic Hydrocarbons - analysis ; Polymorphism, Genetic ; Proteins - genetics ; Transcription Factors ; Tumors ; Xeroderma Pigmentosum Group D Protein</subject><ispartof>Breast cancer research and treatment, 2002-09, Vol.75 (2), p.159-166</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Sep 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-96d9cc79e6973c6e9a7aa83d44ce35783f75c60d5c3d77e99f7f7b701ebf224c3</citedby><cites>FETCH-LOGICAL-c350t-96d9cc79e6973c6e9a7aa83d44ce35783f75c60d5c3d77e99f7f7b701ebf224c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13883733$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12243508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DELIANG TANG</creatorcontrib><creatorcontrib>STAN CHO</creatorcontrib><creatorcontrib>RUNDLE, Andrew</creatorcontrib><creatorcontrib>SENQING CHEN</creatorcontrib><creatorcontrib>PHILLIPS, David</creatorcontrib><creatorcontrib>JINGZHI ZHOU</creatorcontrib><creatorcontrib>YANZHI HSU</creatorcontrib><creatorcontrib>SCHNABEL, Freya</creatorcontrib><creatorcontrib>ESTABROOK, Alison</creatorcontrib><creatorcontrib>PERERA, Frederica P</creatorcontrib><title>Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>We present findings on the associations between DNA adduct levels in breast tissue, risk of breast cancer, and polymorphisms in the DNA repair enzyme XPD. Breast cancer cases, benign breast disease (BBD) controls, and healthy controls were enrolled. Polycyclic aromatic hydrocarbons (PAH)-DNA adduct levels were measured by immunohistochemistry in breast tissue samples from cases and BBD controls. XPD polymorphisms at codons 312 and 751 was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis using white blood cell DNA. Neither of the polymorphisms were associated with case-control status, both in comparisons of cases and BBD controls, and cases and healthy controls. XPD polymorphisms at codons 312 and 751 were associated with higher levels of PAH-DNA in tumor tissue from breast cancer cases. Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s. 0.33 OD, p < 0.01). PAH-DNA adducts were associated with increasing copy number of the Gln allele for the codon 751 polymorphism (p for trend <0.01). Among subjects with the Asp/Asn or Asn/Asn genotype at codon 312, adduct levels were higher in tumor tissue compared to tissue from BBD controls (0.55 OD v.s. 0.36 OD, p = 0.003). Among subjects with the Gln/Gln genotype at codon 751 adduct levels were higher in tumor tissue compared to tissue from BBD controls (0.68 OD v.s. 0.40 OD, p = 0.01). The trend of increasing PAH-DNA adduct levels with either the Asn/Asn or Gln/Gln genotype was greater in tumor tissue than the trend in BBD control tissue.</description><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Case-Control Studies</subject><subject>DNA Adducts - analysis</subject><subject>DNA Helicases</subject><subject>DNA Repair</subject><subject>DNA-Binding Proteins</subject><subject>Female</subject><subject>Genotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Polymorphism, Genetic</subject><subject>Proteins - genetics</subject><subject>Transcription Factors</subject><subject>Tumors</subject><subject>Xeroderma Pigmentosum Group D Protein</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUFr3DAUhEVpaLZJz70VUWhvTiTLtqzcTNImgdDsoYXejPbpmXWwrY2e3LL5C_nT0TYLIT0JoW-G0QxjH6U4kSJXp82ZFNJURpWikLV6wxay1CrTudRv2ULISmdVLapD9p7oTghhtDDv2KHM8yJJ6gV7XPphO_qwWfc0Eu8nHtfIL340PODG9oHj9LAdkf9eXnAbkFsiD72N6PjfPq6TAAJaStcB_-BA3Hd82VxlOwfr3Azxn6nlkKAM_BSDHzjF2W136GonjulxAgzH7KCzA-GH_XnEfn3_9vP8Kru5vbw-b24ySJljZipnALTBymgFFRqrra2VKwpAVepadbqESrgSlNMajel0p1daSFx16d-gjtjXZ99N8PczUmzHngCHwU7oZ2pTe0Kbuk7g5__AOz-HKWVrc5kXRWpTJej0GYLgiQJ27Sb0ow3bVop2N1LbtK9GSopPe9t5NaJ74ferJODLHrAEduhCqqenF06lbFop9QTS4Zkm</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>DELIANG TANG</creator><creator>STAN CHO</creator><creator>RUNDLE, Andrew</creator><creator>SENQING CHEN</creator><creator>PHILLIPS, David</creator><creator>JINGZHI ZHOU</creator><creator>YANZHI HSU</creator><creator>SCHNABEL, Freya</creator><creator>ESTABROOK, Alison</creator><creator>PERERA, Frederica P</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer</title><author>DELIANG TANG ; STAN CHO ; RUNDLE, Andrew ; SENQING CHEN ; PHILLIPS, David ; JINGZHI ZHOU ; YANZHI HSU ; SCHNABEL, Freya ; ESTABROOK, Alison ; PERERA, Frederica P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-96d9cc79e6973c6e9a7aa83d44ce35783f75c60d5c3d77e99f7f7b701ebf224c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - chemistry</topic><topic>Breast Neoplasms - genetics</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Case-Control Studies</topic><topic>DNA Adducts - analysis</topic><topic>DNA Helicases</topic><topic>DNA Repair</topic><topic>DNA-Binding Proteins</topic><topic>Female</topic><topic>Genotype</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Polymorphism, Genetic</topic><topic>Proteins - genetics</topic><topic>Transcription Factors</topic><topic>Tumors</topic><topic>Xeroderma Pigmentosum Group D Protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DELIANG TANG</creatorcontrib><creatorcontrib>STAN CHO</creatorcontrib><creatorcontrib>RUNDLE, Andrew</creatorcontrib><creatorcontrib>SENQING CHEN</creatorcontrib><creatorcontrib>PHILLIPS, David</creatorcontrib><creatorcontrib>JINGZHI ZHOU</creatorcontrib><creatorcontrib>YANZHI HSU</creatorcontrib><creatorcontrib>SCHNABEL, Freya</creatorcontrib><creatorcontrib>ESTABROOK, Alison</creatorcontrib><creatorcontrib>PERERA, Frederica P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DELIANG TANG</au><au>STAN CHO</au><au>RUNDLE, Andrew</au><au>SENQING CHEN</au><au>PHILLIPS, David</au><au>JINGZHI ZHOU</au><au>YANZHI HSU</au><au>SCHNABEL, Freya</au><au>ESTABROOK, Alison</au><au>PERERA, Frederica P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>75</volume><issue>2</issue><spage>159</spage><epage>166</epage><pages>159-166</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>We present findings on the associations between DNA adduct levels in breast tissue, risk of breast cancer, and polymorphisms in the DNA repair enzyme XPD. Breast cancer cases, benign breast disease (BBD) controls, and healthy controls were enrolled. Polycyclic aromatic hydrocarbons (PAH)-DNA adduct levels were measured by immunohistochemistry in breast tissue samples from cases and BBD controls. XPD polymorphisms at codons 312 and 751 was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis using white blood cell DNA. Neither of the polymorphisms were associated with case-control status, both in comparisons of cases and BBD controls, and cases and healthy controls. XPD polymorphisms at codons 312 and 751 were associated with higher levels of PAH-DNA in tumor tissue from breast cancer cases. Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s. 0.33 OD, p < 0.01). PAH-DNA adducts were associated with increasing copy number of the Gln allele for the codon 751 polymorphism (p for trend <0.01). Among subjects with the Asp/Asn or Asn/Asn genotype at codon 312, adduct levels were higher in tumor tissue compared to tissue from BBD controls (0.55 OD v.s. 0.36 OD, p = 0.003). Among subjects with the Gln/Gln genotype at codon 751 adduct levels were higher in tumor tissue compared to tissue from BBD controls (0.68 OD v.s. 0.40 OD, p = 0.01). The trend of increasing PAH-DNA adduct levels with either the Asn/Asn or Gln/Gln genotype was greater in tumor tissue than the trend in BBD control tissue.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>12243508</pmid><doi>10.1023/A:1019693504183</doi><tpages>8</tpages></addata></record> |
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| subjects | Analysis of Variance Biological and medical sciences Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - genetics Cancer research Cancer therapies Case-Control Studies DNA Adducts - analysis DNA Helicases DNA Repair DNA-Binding Proteins Female Genotype Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Polycyclic Aromatic Hydrocarbons - analysis Polymorphism, Genetic Proteins - genetics Transcription Factors Tumors Xeroderma Pigmentosum Group D Protein |
| title | Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer |
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