Metabolism of ethanol by rat hepatocytes results in generation of a lipid chemotactic factor: Studies using a cell-free system and role of oxygen-derived free radicals

We have reported that liver cells metabolizing ethanol release a lipid that has chemotactic activity for human polymorphonuclear leukocytes. The purpose of the present study was to investigate the role of ethanol and of oxygen-derived free radicals in generation of this activity. A cell-free, ethano...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1991-06, Vol.287 (1), p.218-224
Hauptverfasser:	Roll, F.Joseph, Alexander, Michele A., Cua, David, Swanson, William, Perez, H.Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Catalase - pharmacology Cell-Free System chemotactic factors Chemotactic Factors - metabolism Chemotaxis, Leukocyte Chromatography, High Pressure Liquid Cytosol - metabolism ethanol Ethanol - metabolism Free Radicals leukocytes (polymorphonuclear) Lipid Metabolism Liver - drug effects Liver - metabolism Male Mannitol - pharmacology Medical sciences Microsomes, Liver - metabolism Mitochondria, Liver - metabolism Neutrophils - physiology Oxygen - metabolism Rats Rats, Inbred Strains Superoxide Dismutase - pharmacology Toxicology
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