Transport of cis- and trans-4-[ 18F]fluoro-L-proline in F98 glioma cells

The transport mechanisms of cis-4-[ 18F]fluoro-L-proline (cis-FPro) and trans-4-[ 18F]fluoro-L-proline (trans-FPro) were studied in F98 rat glioma cells in comparison to the natural parent [ 3H]-L-proline. Uptake rates of cis-FPro and trans-FPro in F98 glioma cells were 50–70% lower than those of [...

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Veröffentlicht in:	Nuclear medicine and biology 2002-08, Vol.29 (6), p.685-692
Hauptverfasser:	Langen, Karl-J, Mühlensiepen, Heinz, Schmieder, Sven, Hamacher, Kurt, Bröer, Stefan, Börner, Anne R, Schneeweiss, Frank H.A, Coenen, Heinz H
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen - diagnostic imaging Adult Amino acid transport Animals Back - diagnostic imaging Biological and medical sciences Biological Transport, Active Cis- and trans-4-[ 18F]fluoro-L-proline Female Glioma - diagnostic imaging Glioma - metabolism Glioma cells Humans Medical sciences PET Proline - analogs & derivatives Proline - pharmacokinetics Radiopharmaceuticals Rats Reference Values Sensitivity and Specificity Thorax - diagnostic imaging Thorax - metabolism Tissue Distribution Tomography, Emission-Computed Tumor Cells, Cultured Whole body distribution Whole-Body Counting
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