Salen−Manganese Complexes as Catalytic Scavengers of Hydrogen Peroxide and Cytoprotective Agents:  Structure−Activity Relationship Studies

Synthetic catalytic scavengers of reactive oxygen species (ROS) may have broad clinical applicability. In previous papers, two salen−manganese complexes, EUK-8 and EUK-134, had superoxide dismutase (SOD) and catalase activities and prevented ROS-associated tissue injury. This study describes two ser...

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Veröffentlicht in:Journal of medicinal chemistry 2002-09, Vol.45 (20), p.4549-4558
Hauptverfasser: Doctrow, Susan R, Huffman, Karl, Marcus, Catherine Bucay, Tocco, Georges, Malfroy, Evelyne, Adinolfi, Christy A, Kruk, Henry, Baker, Keith, Lazarowych, Natalie, Mascarenhas, Julius, Malfroy, Bernard
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Sprache:eng
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