Quantification of sugars and organic acids in hygroscopic pharmaceutical herbal dry extracts
Three chromatographic methods have been employed for the determination of hydrophilic compounds, namely carbohydrates and organic acids in herbal dry extracts of Eschscholtzia californica Cham. The hydrophilic compounds were separated from the other components of the dry extracts by solid-phase extr...
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| Veröffentlicht in: | Journal of Chromatography A 2002-08, Vol.968 (1), p.101-111 |
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| container_title | Journal of Chromatography A |
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| creator | Schiller, Marc von der Heydt, Holger März, Frieder Schmidt, Peter C |
| description | Three chromatographic methods have been employed for the determination of hydrophilic compounds, namely carbohydrates and organic acids in herbal dry extracts of
Eschscholtzia californica Cham. The hydrophilic compounds were separated from the other components of the dry extracts by solid-phase extraction methods, which were optimised with respect to recovery rates. Carbohydrates were quantified using high-performance anion-exchange chromatography with pulsed amperometric detection. Organic acids were analysed by ion-exclusion chromatography with evaporative light scattering detection and gas chromatography–mass spectrometry. Using the latter method, large amounts of glyceric acid were separated from the extracts of
Eschscholtzia californica Cham. This substance together with sugars may be responsible for the increased hygroscopicity and the poor processing behaviour of the extracts. |
| doi_str_mv | 10.1016/S0021-9673(02)00949-4 |
| format | Article |
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Eschscholtzia californica Cham. The hydrophilic compounds were separated from the other components of the dry extracts by solid-phase extraction methods, which were optimised with respect to recovery rates. Carbohydrates were quantified using high-performance anion-exchange chromatography with pulsed amperometric detection. Organic acids were analysed by ion-exclusion chromatography with evaporative light scattering detection and gas chromatography–mass spectrometry. Using the latter method, large amounts of glyceric acid were separated from the extracts of
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Eschscholtzia californica Cham. The hydrophilic compounds were separated from the other components of the dry extracts by solid-phase extraction methods, which were optimised with respect to recovery rates. Carbohydrates were quantified using high-performance anion-exchange chromatography with pulsed amperometric detection. Organic acids were analysed by ion-exclusion chromatography with evaporative light scattering detection and gas chromatography–mass spectrometry. Using the latter method, large amounts of glyceric acid were separated from the extracts of
Eschscholtzia californica Cham. This substance together with sugars may be responsible for the increased hygroscopicity and the poor processing behaviour of the extracts.</description><subject>Acids - analysis</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates</subject><subject>Carbohydrates - analysis</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Ion Exchange - methods</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General pharmacology</subject><subject>Glyceric acid</subject><subject>Herbal Medicine</subject><subject>Hydrolysis</subject><subject>Medical sciences</subject><subject>Organic acids</subject><subject>Organic Chemicals - analysis</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Reproducibility of Results</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhn0AtaXwE0C-gOghdPyRODkhVEFBqlRVwA3Jmownu0a7yWIniP33uN0VPXIaafS88_EI8VLBOwWqufwKoFXVNc68BX0B0Nmusk_E2b_2qXiW808A5cDpE3GqtDaN7cyZ-HG34DjHIRLOcRrlNMi8rDBliWOQU1rhGEkixZBlHOV6v0pTpmlXmrs1pi0SL3MJb-SaU19KSHvJf-aENOfn4umAm8wvjvVcfP_08dvV5-rm9vrL1Yebikyn5sqZgBRaarsQGuuCtrVtezYdQou2Dq43mrAxmhUQ1r1moyyYWusWO93W5ly8OczdpenXwnn225iJNxsceVqyd1qBhVoVsD6AVL7IiQe_S3GLae8V-HuV_kGlv3fmQfsHld6W3KvjgqXfcnhMHT0W4PURwFxkDAlHivmRM61tndOFe3_guOj4HTn5TJFH4hAT0-zDFP9zyl8zgpLf</recordid><startdate>20020830</startdate><enddate>20020830</enddate><creator>Schiller, Marc</creator><creator>von der Heydt, Holger</creator><creator>März, Frieder</creator><creator>Schmidt, Peter C</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020830</creationdate><title>Quantification of sugars and organic acids in hygroscopic pharmaceutical herbal dry extracts</title><author>Schiller, Marc ; von der Heydt, Holger ; März, Frieder ; Schmidt, Peter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-73dacd8c89dd647d24548be39a08a45d7b32ca632e10ca5b2e314035228a92853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acids - analysis</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates</topic><topic>Carbohydrates - analysis</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, Ion Exchange - methods</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General pharmacology</topic><topic>Glyceric acid</topic><topic>Herbal Medicine</topic><topic>Hydrolysis</topic><topic>Medical sciences</topic><topic>Organic acids</topic><topic>Organic Chemicals - analysis</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiller, Marc</creatorcontrib><creatorcontrib>von der Heydt, Holger</creatorcontrib><creatorcontrib>März, Frieder</creatorcontrib><creatorcontrib>Schmidt, Peter C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiller, Marc</au><au>von der Heydt, Holger</au><au>März, Frieder</au><au>Schmidt, Peter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of sugars and organic acids in hygroscopic pharmaceutical herbal dry extracts</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2002-08-30</date><risdate>2002</risdate><volume>968</volume><issue>1</issue><spage>101</spage><epage>111</epage><pages>101-111</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>Three chromatographic methods have been employed for the determination of hydrophilic compounds, namely carbohydrates and organic acids in herbal dry extracts of
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| subjects | Acids - analysis Biological and medical sciences Carbohydrates Carbohydrates - analysis Chromatography, High Pressure Liquid - methods Chromatography, Ion Exchange - methods Gas Chromatography-Mass Spectrometry General pharmacology Glyceric acid Herbal Medicine Hydrolysis Medical sciences Organic acids Organic Chemicals - analysis Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plants, Medicinal - chemistry Reproducibility of Results |
| title | Quantification of sugars and organic acids in hygroscopic pharmaceutical herbal dry extracts |
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