Malignant schwannoma associated with xeroderma pigmentosum in a patient belonging to complementation group D
A 43-year-old man with xeroderma pigmentosum, XP97TO, was allocated to complementation group D. He had had moderate photosensitivity at age 1 year and freckles by age 6 but no neurologic abnormalities. Nevertheless, his fibroblasts in culture had the XP-D phenotype. They showed a sevenfold hypersens...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1991-08, Vol.25 (2), p.349-353 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Nakamura, Takehiko Ono, Tomomichi Yoshimura, Koji Arao, Tatsuyoshi Kondo, Seiji Ichihashi, Masamitsu Matsumoto, Akira Fujiwara, Yoshisada |
| description | A 43-year-old man with xeroderma pigmentosum, XP97TO, was allocated to complementation group D. He had had moderate photosensitivity at age 1 year and freckles by age 6 but no neurologic abnormalities. Nevertheless, his fibroblasts in culture had the XP-D phenotype. They showed a sevenfold hypersensitivity to killing by 254 rim ultraviolet radiation and a diminished level (29%) of unscheduled DNA synthesis. Phototesting revealed delayed maximum erythema at 72 hours after UVB exposure and a lowered minimal erythema dose. Lentigo maligna developed on the patient's face, and a rapidly growing malignant schwannoma was found on the left trigeminal nerve. This may be the first case of a peripheral nervous tissue neoplasm in xeroderma pigmentosum. |
| doi_str_mv | 10.1016/0190-9622(91)70202-D |
| format | Article |
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He had had moderate photosensitivity at age 1 year and freckles by age 6 but no neurologic abnormalities. Nevertheless, his fibroblasts in culture had the XP-D phenotype. They showed a sevenfold hypersensitivity to killing by 254 rim ultraviolet radiation and a diminished level (29%) of unscheduled DNA synthesis. Phototesting revealed delayed maximum erythema at 72 hours after UVB exposure and a lowered minimal erythema dose. Lentigo maligna developed on the patient's face, and a rapidly growing malignant schwannoma was found on the left trigeminal nerve. This may be the first case of a peripheral nervous tissue neoplasm in xeroderma pigmentosum.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/0190-9622(91)70202-D</identifier><identifier>PMID: 1894771</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Biological and medical sciences ; Cranial Nerve Neoplasms ; Dermatology ; Facial Dermatoses - classification ; Facial Dermatoses - pathology ; Facial Neoplasms - pathology ; Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue ; Humans ; Male ; Medical sciences ; Melanoma - pathology ; Neoplasms, Multiple Primary - pathology ; Neurilemmoma - pathology ; Skin Neoplasms - pathology ; Trigeminal Nerve ; Xeroderma Pigmentosum - classification ; Xeroderma Pigmentosum - pathology</subject><ispartof>Journal of the American Academy of Dermatology, 1991-08, Vol.25 (2), p.349-353</ispartof><rights>1991 American Academy of Dermatology, Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-960282825d9e72e13ce12b6cf8d35c4acfc44f98f84d2e481db7f54b2843865f3</citedby><cites>FETCH-LOGICAL-c386t-960282825d9e72e13ce12b6cf8d35c4acfc44f98f84d2e481db7f54b2843865f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0190-9622(91)70202-D$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5600238$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1894771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Takehiko</creatorcontrib><creatorcontrib>Ono, Tomomichi</creatorcontrib><creatorcontrib>Yoshimura, Koji</creatorcontrib><creatorcontrib>Arao, Tatsuyoshi</creatorcontrib><creatorcontrib>Kondo, Seiji</creatorcontrib><creatorcontrib>Ichihashi, Masamitsu</creatorcontrib><creatorcontrib>Matsumoto, Akira</creatorcontrib><creatorcontrib>Fujiwara, Yoshisada</creatorcontrib><title>Malignant schwannoma associated with xeroderma pigmentosum in a patient belonging to complementation group D</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>A 43-year-old man with xeroderma pigmentosum, XP97TO, was allocated to complementation group D. He had had moderate photosensitivity at age 1 year and freckles by age 6 but no neurologic abnormalities. Nevertheless, his fibroblasts in culture had the XP-D phenotype. They showed a sevenfold hypersensitivity to killing by 254 rim ultraviolet radiation and a diminished level (29%) of unscheduled DNA synthesis. Phototesting revealed delayed maximum erythema at 72 hours after UVB exposure and a lowered minimal erythema dose. Lentigo maligna developed on the patient's face, and a rapidly growing malignant schwannoma was found on the left trigeminal nerve. This may be the first case of a peripheral nervous tissue neoplasm in xeroderma pigmentosum.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cranial Nerve Neoplasms</subject><subject>Dermatology</subject><subject>Facial Dermatoses - classification</subject><subject>Facial Dermatoses - pathology</subject><subject>Facial Neoplasms - pathology</subject><subject>Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - pathology</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neurilemmoma - pathology</subject><subject>Skin Neoplasms - pathology</subject><subject>Trigeminal Nerve</subject><subject>Xeroderma Pigmentosum - classification</subject><subject>Xeroderma Pigmentosum - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2P1SAUhonRjHdG_4EmLIwZF1WgtMBmEjPXr2SMG10TSg8dTAsVqKP_Xq73ZtwZFiTnfd6TkwehZ5S8poT2bwhVpFE9Y5eKvhKEEdbsH6AdJUo0vZDiIdrdI4_Rec7fCSGKt-IMnVGpuBB0h-bPZvZTMKHgbG_vTAhxMdjkHK03BUZ858st_gUpjpBqsvppgVBi3hbsA64DU3wd4AHmGCYfJlwitnFZZziANY0BTyluK94_QY-cmTM8Pf0X6Nv7d1-vPzY3Xz58un5709hW9qUeTJisrxsVCAa0tUDZ0Fsnx7az3FhnOXdKOslHBlzScRCu4wOTvPY7116gl8e9a4o_NshFLz5bmGcTIG5ZC0ZJqxSpID-CNsWcEzi9Jr-Y9FtTog-S9cGgPhjUiuq_kvW-1p6f9m_DAuO_0tFqzV-ccpOtmV0ywfp8j3U9IayVFbs6YlBd_PSQdLbVpYXRJ7BFj9H__44_4MSaFA</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>Nakamura, Takehiko</creator><creator>Ono, Tomomichi</creator><creator>Yoshimura, Koji</creator><creator>Arao, Tatsuyoshi</creator><creator>Kondo, Seiji</creator><creator>Ichihashi, Masamitsu</creator><creator>Matsumoto, Akira</creator><creator>Fujiwara, Yoshisada</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910801</creationdate><title>Malignant schwannoma associated with xeroderma pigmentosum in a patient belonging to complementation group D</title><author>Nakamura, Takehiko ; Ono, Tomomichi ; Yoshimura, Koji ; Arao, Tatsuyoshi ; Kondo, Seiji ; Ichihashi, Masamitsu ; Matsumoto, Akira ; Fujiwara, Yoshisada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-960282825d9e72e13ce12b6cf8d35c4acfc44f98f84d2e481db7f54b2843865f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cranial Nerve Neoplasms</topic><topic>Dermatology</topic><topic>Facial Dermatoses - classification</topic><topic>Facial Dermatoses - pathology</topic><topic>Facial Neoplasms - pathology</topic><topic>Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - pathology</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neurilemmoma - pathology</topic><topic>Skin Neoplasms - pathology</topic><topic>Trigeminal Nerve</topic><topic>Xeroderma Pigmentosum - classification</topic><topic>Xeroderma Pigmentosum - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Takehiko</creatorcontrib><creatorcontrib>Ono, Tomomichi</creatorcontrib><creatorcontrib>Yoshimura, Koji</creatorcontrib><creatorcontrib>Arao, Tatsuyoshi</creatorcontrib><creatorcontrib>Kondo, Seiji</creatorcontrib><creatorcontrib>Ichihashi, Masamitsu</creatorcontrib><creatorcontrib>Matsumoto, Akira</creatorcontrib><creatorcontrib>Fujiwara, Yoshisada</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Takehiko</au><au>Ono, Tomomichi</au><au>Yoshimura, Koji</au><au>Arao, Tatsuyoshi</au><au>Kondo, Seiji</au><au>Ichihashi, Masamitsu</au><au>Matsumoto, Akira</au><au>Fujiwara, Yoshisada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant schwannoma associated with xeroderma pigmentosum in a patient belonging to complementation group D</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1991-08-01</date><risdate>1991</risdate><volume>25</volume><issue>2</issue><spage>349</spage><epage>353</epage><pages>349-353</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>A 43-year-old man with xeroderma pigmentosum, XP97TO, was allocated to complementation group D. He had had moderate photosensitivity at age 1 year and freckles by age 6 but no neurologic abnormalities. Nevertheless, his fibroblasts in culture had the XP-D phenotype. They showed a sevenfold hypersensitivity to killing by 254 rim ultraviolet radiation and a diminished level (29%) of unscheduled DNA synthesis. Phototesting revealed delayed maximum erythema at 72 hours after UVB exposure and a lowered minimal erythema dose. Lentigo maligna developed on the patient's face, and a rapidly growing malignant schwannoma was found on the left trigeminal nerve. This may be the first case of a peripheral nervous tissue neoplasm in xeroderma pigmentosum.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>1894771</pmid><doi>10.1016/0190-9622(91)70202-D</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of the American Academy of Dermatology, 1991-08, Vol.25 (2), p.349-353 |
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| subjects | Adult Biological and medical sciences Cranial Nerve Neoplasms Dermatology Facial Dermatoses - classification Facial Dermatoses - pathology Facial Neoplasms - pathology Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue Humans Male Medical sciences Melanoma - pathology Neoplasms, Multiple Primary - pathology Neurilemmoma - pathology Skin Neoplasms - pathology Trigeminal Nerve Xeroderma Pigmentosum - classification Xeroderma Pigmentosum - pathology |
| title | Malignant schwannoma associated with xeroderma pigmentosum in a patient belonging to complementation group D |
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