Coexistence of donor and host T lymphocytes following HLA-different bone marrow transplantation into a patient with cellular immunodeficiency and nonfunctional CD4+ T cells
We report the outcome of a non-T-cell-depleted bone marrow transplant from an HLA partially incompatible, MLR-positive, parental donor in a patient with an unusual form of immunodeficiency characterized by a lack of CD8 T cells and a failure of the CD4 cells to display functional activity in vitro....
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| Veröffentlicht in: | Transplantation 1991-09, Vol.52 (3), p.491-496 |
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| container_end_page | 496 |
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| container_issue | 3 |
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| container_title | Transplantation |
| container_volume | 52 |
| creator | KNOBLOCH, C GOLDMANN, S. F HARPPRECHT, J FRIEDRICH, W |
| description | We report the outcome of a non-T-cell-depleted bone marrow transplant from an HLA partially incompatible, MLR-positive, parental donor in a patient with an unusual form of immunodeficiency characterized by a lack of CD8 T cells and a failure of the CD4 cells to display functional activity in vitro. Without conditioning, and following a mild and transient GVHD, donor T cells persist in trace amounts in the host, where they coexist with the nonfunctional host T cells and cooperate with host APC in antigen recognition, thereby leading to a reconstitution of T cell functions in vitro and in vivo and development of a stable, so far unprecedented, human T-T split chimera across MHC barriers. |
| doi_str_mv | 10.1097/00007890-199109000-00020 |
| format | Article |
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Without conditioning, and following a mild and transient GVHD, donor T cells persist in trace amounts in the host, where they coexist with the nonfunctional host T cells and cooperate with host APC in antigen recognition, thereby leading to a reconstitution of T cell functions in vitro and in vivo and development of a stable, so far unprecedented, human T-T split chimera across MHC barriers.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199109000-00020</identifier><identifier>PMID: 1832794</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antigens, Differentiation, T-Lymphocyte - analysis ; B-Lymphocytes - physiology ; Biological and medical sciences ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; CD4 Antigens - analysis ; CD8 Antigens ; Female ; HLA-A Antigens - immunology ; Humans ; Immunologic Deficiency Syndromes - immunology ; Infant ; Interleukin-2 - pharmacology ; Lymphocyte Culture Test, Mixed ; Medical sciences ; T-Lymphocytes - physiology ; Transfusions. Complications. Transfusion reactions. 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F</creatorcontrib><creatorcontrib>HARPPRECHT, J</creatorcontrib><creatorcontrib>FRIEDRICH, W</creatorcontrib><title>Coexistence of donor and host T lymphocytes following HLA-different bone marrow transplantation into a patient with cellular immunodeficiency and nonfunctional CD4+ T cells</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>We report the outcome of a non-T-cell-depleted bone marrow transplant from an HLA partially incompatible, MLR-positive, parental donor in a patient with an unusual form of immunodeficiency characterized by a lack of CD8 T cells and a failure of the CD4 cells to display functional activity in vitro. Without conditioning, and following a mild and transient GVHD, donor T cells persist in trace amounts in the host, where they coexist with the nonfunctional host T cells and cooperate with host APC in antigen recognition, thereby leading to a reconstitution of T cell functions in vitro and in vivo and development of a stable, so far unprecedented, human T-T split chimera across MHC barriers.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antigens, Differentiation, T-Lymphocyte - analysis</subject><subject>B-Lymphocytes - physiology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>CD4 Antigens - analysis</subject><subject>CD8 Antigens</subject><subject>Female</subject><subject>HLA-A Antigens - immunology</subject><subject>Humans</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>Infant</subject><subject>Interleukin-2 - pharmacology</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Medical sciences</subject><subject>T-Lymphocytes - physiology</subject><subject>Transfusions. Complications. Transfusion reactions. 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F</au><au>HARPPRECHT, J</au><au>FRIEDRICH, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coexistence of donor and host T lymphocytes following HLA-different bone marrow transplantation into a patient with cellular immunodeficiency and nonfunctional CD4+ T cells</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1991-09</date><risdate>1991</risdate><volume>52</volume><issue>3</issue><spage>491</spage><epage>496</epage><pages>491-496</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>We report the outcome of a non-T-cell-depleted bone marrow transplant from an HLA partially incompatible, MLR-positive, parental donor in a patient with an unusual form of immunodeficiency characterized by a lack of CD8 T cells and a failure of the CD4 cells to display functional activity in vitro. Without conditioning, and following a mild and transient GVHD, donor T cells persist in trace amounts in the host, where they coexist with the nonfunctional host T cells and cooperate with host APC in antigen recognition, thereby leading to a reconstitution of T cell functions in vitro and in vivo and development of a stable, so far unprecedented, human T-T split chimera across MHC barriers.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>1832794</pmid><doi>10.1097/00007890-199109000-00020</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1991-09, Vol.52 (3), p.491-496 |
| issn | 0041-1337 1534-6080 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72103362 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, Differentiation, T-Lymphocyte - analysis B-Lymphocytes - physiology Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction CD4 Antigens - analysis CD8 Antigens Female HLA-A Antigens - immunology Humans Immunologic Deficiency Syndromes - immunology Infant Interleukin-2 - pharmacology Lymphocyte Culture Test, Mixed Medical sciences T-Lymphocytes - physiology Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Coexistence of donor and host T lymphocytes following HLA-different bone marrow transplantation into a patient with cellular immunodeficiency and nonfunctional CD4+ T cells |
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