Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study
Histopathologic examination was done on 18 cases after percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma. In eight cases, the lesion was treated by PEIT alone; in the other ten cases, PEIT was combined with transcatheter arterial embolization. The lesion was completely necro...
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| Veröffentlicht in: | Cancer 1991-10, Vol.68 (7), p.1524-1530 |
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| creator | Shiina, Shuichiro Tagawa, Kazumi Unuma, Tadao Takanashi, Riichiro Yoshiura, Kenta Komatsu, Yutaka Hata, Yasuo Niwa, Yasuro Shiratori, Yasushi Terano, Akira Sugimoto, Tsuneaki |
| description | Histopathologic examination was done on 18 cases after percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma. In eight cases, the lesion was treated by PEIT alone; in the other ten cases, PEIT was combined with transcatheter arterial embolization. The lesion was completely necrotic in 13 cases, 90% necrotic in four cases, and 70% necrotic in the rest. In addition, PEIT seemed to be effective against intercapsular, extracapsular, and vascular invasions. In the four cases of incomplete necrosis, the viable cancer tissue remained in small tumor nodules around the main tumor, in portions isolated by septa, or along the edge of the lesion. Therefore, ethanol should be injected not only into the center of the lesion, but also into sites close to its edge. Ethanol did not damage noncancerous liver parenchyma distant from injected sites. Local dissemination of the cancer cells was not found in any case. Therefore, PEIT seems to be a valuable therapy and may be an alternative to surgery in some cases. |
| doi_str_mv | 10.1002/1097-0142(19911001)68:7<1524::AID-CNCR2820680711>3.0.CO;2-O |
| format | Article |
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A histopathologic study</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Shiina, Shuichiro ; Tagawa, Kazumi ; Unuma, Tadao ; Takanashi, Riichiro ; Yoshiura, Kenta ; Komatsu, Yutaka ; Hata, Yasuo ; Niwa, Yasuro ; Shiratori, Yasushi ; Terano, Akira ; Sugimoto, Tsuneaki</creator><creatorcontrib>Shiina, Shuichiro ; Tagawa, Kazumi ; Unuma, Tadao ; Takanashi, Riichiro ; Yoshiura, Kenta ; Komatsu, Yutaka ; Hata, Yasuo ; Niwa, Yasuro ; Shiratori, Yasushi ; Terano, Akira ; Sugimoto, Tsuneaki</creatorcontrib><description>Histopathologic examination was done on 18 cases after percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma. In eight cases, the lesion was treated by PEIT alone; in the other ten cases, PEIT was combined with transcatheter arterial embolization. The lesion was completely necrotic in 13 cases, 90% necrotic in four cases, and 70% necrotic in the rest. In addition, PEIT seemed to be effective against intercapsular, extracapsular, and vascular invasions. In the four cases of incomplete necrosis, the viable cancer tissue remained in small tumor nodules around the main tumor, in portions isolated by septa, or along the edge of the lesion. Therefore, ethanol should be injected not only into the center of the lesion, but also into sites close to its edge. Ethanol did not damage noncancerous liver parenchyma distant from injected sites. Local dissemination of the cancer cells was not found in any case. Therefore, PEIT seems to be a valuable therapy and may be an alternative to surgery in some cases.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19911001)68:7<1524::AID-CNCR2820680711>3.0.CO;2-O</identifier><identifier>PMID: 1654196</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Biological and medical sciences ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - therapy ; Chemotherapy ; Combined Modality Therapy ; Embolization, Therapeutic ; Ethanol - administration & dosage ; Ethanol - therapeutic use ; Female ; Humans ; Injections, Intralesional ; Liver Neoplasms - pathology ; Liver Neoplasms - therapy ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Ultrasonics</subject><ispartof>Cancer, 1991-10, Vol.68 (7), p.1524-1530</ispartof><rights>Copyright © 1991 American Cancer Society</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5641-b9e49f1694cad63d5ff0484dc6287da6b633224707288731314cb775f557f2bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4458265$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1654196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shiina, Shuichiro</creatorcontrib><creatorcontrib>Tagawa, Kazumi</creatorcontrib><creatorcontrib>Unuma, Tadao</creatorcontrib><creatorcontrib>Takanashi, Riichiro</creatorcontrib><creatorcontrib>Yoshiura, Kenta</creatorcontrib><creatorcontrib>Komatsu, Yutaka</creatorcontrib><creatorcontrib>Hata, Yasuo</creatorcontrib><creatorcontrib>Niwa, Yasuro</creatorcontrib><creatorcontrib>Shiratori, Yasushi</creatorcontrib><creatorcontrib>Terano, Akira</creatorcontrib><creatorcontrib>Sugimoto, Tsuneaki</creatorcontrib><title>Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Histopathologic examination was done on 18 cases after percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma. In eight cases, the lesion was treated by PEIT alone; in the other ten cases, PEIT was combined with transcatheter arterial embolization. The lesion was completely necrotic in 13 cases, 90% necrotic in four cases, and 70% necrotic in the rest. In addition, PEIT seemed to be effective against intercapsular, extracapsular, and vascular invasions. In the four cases of incomplete necrosis, the viable cancer tissue remained in small tumor nodules around the main tumor, in portions isolated by septa, or along the edge of the lesion. Therefore, ethanol should be injected not only into the center of the lesion, but also into sites close to its edge. Ethanol did not damage noncancerous liver parenchyma distant from injected sites. Local dissemination of the cancer cells was not found in any case. Therefore, PEIT seems to be a valuable therapy and may be an alternative to surgery in some cases.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>Chemotherapy</subject><subject>Combined Modality Therapy</subject><subject>Embolization, Therapeutic</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intralesional</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Ultrasonics</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkN2L1DAUxYMo67j6Jwh9ENGHjrn57qwIQ_1aWKyIgqAQ0jRxunSaMWmR-e9t6biiD4JP4eacezj3h1AJeA0Yk2eAC5ljYOQJFAVMX_BUqI18DpywzWZ7-TIv35UfiCJYKCwBXtA1XpfVBcmrW2h1s30brTDGKueMfr6L7qV0PY2ScHqGzkBwBoVYoa_vXbTjYHoXxpS5YWf60GVtf-3s0IY-G3YumsMx8yFmO3cwQ7Cu68bOxMyaaNs-7M0622a7Ng1hknehC99am6VhbI730R1vuuQenN5z9On1q4_l2_yqenNZbq9yywWDvC4cKzyIglnTCNpw7zFTrLGCKNkYUQtKCWFyKq-UpECB2VpK7jmXntSWnqPHS-4hhu-jS4Pet2nuuZylJQFMQIrJ-GUx2hhSis7rQ2z3Jh41YD2z1zM9PdPTv9hrobTUM3utJ_b6T_aaaqzLShNdTekPTzXGeu-a39kL7El_dNJNsqbz0fS2TTc2xrgigk82v9h-tJ07_l_Dfxb8S6E_ASRlrsI</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>Shiina, Shuichiro</creator><creator>Tagawa, Kazumi</creator><creator>Unuma, Tadao</creator><creator>Takanashi, Riichiro</creator><creator>Yoshiura, Kenta</creator><creator>Komatsu, Yutaka</creator><creator>Hata, Yasuo</creator><creator>Niwa, Yasuro</creator><creator>Shiratori, Yasushi</creator><creator>Terano, Akira</creator><creator>Sugimoto, Tsuneaki</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19911001</creationdate><title>Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study</title><author>Shiina, Shuichiro ; Tagawa, Kazumi ; Unuma, Tadao ; Takanashi, Riichiro ; Yoshiura, Kenta ; Komatsu, Yutaka ; Hata, Yasuo ; Niwa, Yasuro ; Shiratori, Yasushi ; Terano, Akira ; Sugimoto, Tsuneaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5641-b9e49f1694cad63d5ff0484dc6287da6b633224707288731314cb775f557f2bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>Chemotherapy</topic><topic>Combined Modality Therapy</topic><topic>Embolization, Therapeutic</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intralesional</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Ultrasonics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shiina, Shuichiro</creatorcontrib><creatorcontrib>Tagawa, Kazumi</creatorcontrib><creatorcontrib>Unuma, Tadao</creatorcontrib><creatorcontrib>Takanashi, Riichiro</creatorcontrib><creatorcontrib>Yoshiura, Kenta</creatorcontrib><creatorcontrib>Komatsu, Yutaka</creatorcontrib><creatorcontrib>Hata, Yasuo</creatorcontrib><creatorcontrib>Niwa, Yasuro</creatorcontrib><creatorcontrib>Shiratori, Yasushi</creatorcontrib><creatorcontrib>Terano, Akira</creatorcontrib><creatorcontrib>Sugimoto, Tsuneaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiina, Shuichiro</au><au>Tagawa, Kazumi</au><au>Unuma, Tadao</au><au>Takanashi, Riichiro</au><au>Yoshiura, Kenta</au><au>Komatsu, Yutaka</au><au>Hata, Yasuo</au><au>Niwa, Yasuro</au><au>Shiratori, Yasushi</au><au>Terano, Akira</au><au>Sugimoto, Tsuneaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>68</volume><issue>7</issue><spage>1524</spage><epage>1530</epage><pages>1524-1530</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Histopathologic examination was done on 18 cases after percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma. In eight cases, the lesion was treated by PEIT alone; in the other ten cases, PEIT was combined with transcatheter arterial embolization. The lesion was completely necrotic in 13 cases, 90% necrotic in four cases, and 70% necrotic in the rest. In addition, PEIT seemed to be effective against intercapsular, extracapsular, and vascular invasions. In the four cases of incomplete necrosis, the viable cancer tissue remained in small tumor nodules around the main tumor, in portions isolated by septa, or along the edge of the lesion. Therefore, ethanol should be injected not only into the center of the lesion, but also into sites close to its edge. Ethanol did not damage noncancerous liver parenchyma distant from injected sites. Local dissemination of the cancer cells was not found in any case. Therefore, PEIT seems to be a valuable therapy and may be an alternative to surgery in some cases.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1654196</pmid><doi>10.1002/1097-0142(19911001)68:7<1524::AID-CNCR2820680711>3.0.CO;2-O</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antineoplastic agents Biological and medical sciences Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Chemotherapy Combined Modality Therapy Embolization, Therapeutic Ethanol - administration & dosage Ethanol - therapeutic use Female Humans Injections, Intralesional Liver Neoplasms - pathology Liver Neoplasms - therapy Male Medical sciences Middle Aged Pharmacology. Drug treatments Ultrasonics |
| title | Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study |
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