Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases

Organic osmolytes are used in animal and plant cells to adapt to hyper- and hypoosmolar stress. We used our RBC-membrane model to investigate the effects of the osmolytes betaine, sorbitol and myo-inositol on Na +/K +-ATPase, Ca 2+-ATPase and calmodulin-stimulated Ca 2+-ATPase (CaM). Our results sho...

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Veröffentlicht in:	Life sciences (1973) 2002-10, Vol.71 (20), p.2413-2424
Hauptverfasser:	Moeckel, Gilbert W, Shadman, Ramin, Fogel, Joy M, Sadrzadeh, Sayed M.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - antagonists & inhibitors ATPase Betaine - pharmacology Enzyme Inhibitors - pharmacology Erythrocyte Membrane - enzymology Hypertonicity Inositol - pharmacology Membranes Osmolar Concentration Osmolytes Red blood cells Sorbitol - pharmacology Urea - pharmacology
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