The calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteries

The new dihydropyridine calcium channel antagonist S 11568 and its optical isomers, S 12967 and S 12968 (3 × 10 −6 to 10 −4 M), caused, unlike nifedipine (10 −4 M), equipotent and rapid endothelium-dependent relaxations and increased the content of cyclic GMP in rings of canine femoral arteries. The...

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Veröffentlicht in:	European journal of pharmacology 1991-05, Vol.197 (1), p.41-48
Hauptverfasser:	Vilaine, Jean Paul, Biondi, Maria L., Villeneuve, Nicole, Feletou, Michel, Peglion, Jean-Louis, Vanhoutte, Paul M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - pharmacology Bioassay Biological and medical sciences Ca 2+ channel antagonists Calcium Channel Blockers - pharmacology Cardiovascular system cGMP Coronary artery (dog) Cyclic GMP - metabolism Dihydropyridines - pharmacology Dogs EDRF (endothelium-derived relaxing factor) Endothelium, Vascular - metabolism Endothelium, Vascular - physiology Female Femoral artery (dog) Hemoglobins - metabolism In Vitro Techniques Male Medical sciences Methylene Blue - pharmacology Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Nitric Oxide - pharmacology omega-N-Methylarginine Pharmacology. Drug treatments Vasodilator agents. Cerebral vasodilators
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