Protective function of transcription factor TR3 orphan receptor in atherogenesis: Decreased lesion formation in carotid artery ligation model in TR3 transgenic mice

Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis and restenosis. The precise signaling pathways by which the proliferation of SMCs is regulated are largely unknown. The TR3 orphan receptor, the mitogen-induced nuclear orphan receptor (MINOR), and the nuclear recept...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2002-09, Vol.106 (12), p.1530-1535
Hauptverfasser:	ARKENBOUT, E. Karin, DE WAARD, Vivian, VAN BRAGT, Maaike, VAN ACHTERBERG, Tanja A. E, GRIMBERGEN, Jos M, PICHON, Bruno, PANNEKOEK, Hans, DE VRIES, Carlie J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Arteriosclerosis - etiology Arteriosclerosis - genetics Arteriosclerosis - metabolism Arteriosclerosis - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiotonic Agents - metabolism Carotid Arteries - surgery DNA - biosynthesis DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Genetic Vectors Humans Medical sciences Mice Mice, Transgenic Muscle, Smooth, Vascular - metabolism Mutation Nerve Tissue Proteins Nuclear Receptor Subfamily 4, Group A, Member 1 Nuclear Receptor Subfamily 4, Group A, Member 2 Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Cytoplasmic and Nuclear - genetics Receptors, Steroid Receptors, Thyroid Hormone RNA, Messenger - biosynthesis Transcription Factors - biosynthesis Transcription Factors - genetics Transcription Factors - physiology
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