Expression of v-src induces aberrant development and twinning in chimaeric mice

The role of the proto-oncogene c-src in mouse development has been investigated by studying the consequences of expressing its viral homologue, v-src. Embryonic stem (ES) cell lines with differing levels of v-src tyrosine kinase activity have been used to generate chimaeric mice. Whereas a low level...

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Veröffentlicht in:	Development (Cambridge) 1991-02, Vol.111 (2), p.357-366
Hauptverfasser:	BOULTER, C. A, AGUZZI, A, WILLIAMS, R. L, WAGNER, E. F, EVANS, M. J, BEDDINGTON, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Differentiation - genetics Cell Line Chimera - genetics Congenital Abnormalities - genetics Embryology: invertebrates and vertebrates. Teratology Fundamental and applied biological sciences. Psychology Gene Expression - physiology Genes, src - genetics Mice Molecular embryology Oncogene Proteins, Viral - genetics Protein-Tyrosine Kinases - genetics Stem Cells - physiology Twins
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