Incorporation of Reversibly Cross-Linked Polyplexes into LPDII Vectors for Gene Delivery

LPDII vectors are synthetic vehicles for gene delivery composed of polycation-condensed DNA complexed with anionic liposomes. In this study, we evaluated the stability and transfection properties of polyethylenimine (PEI, 25 kDa)/DNA polyplexes before and after covalent cross-linking with dithiobis(...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioconjugate chemistry 2002-09, Vol.13 (5), p.1044-1053
Hauptverfasser:	Gosselin, Michael A., Guo, Wenjin, Lee, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - metabolism Cross-Linking Reagents - chemistry Diglycerides Drug Stability Folate Receptors, GPI-Anchored folic acid Humans KB Cells Ligands Liposomes Particle Size Plasmids - administration & dosage Plasmids - pharmacokinetics Polyamines - chemical synthesis Polyamines - pharmacokinetics polyethyleneimine Polyethyleneimine - chemistry polyethylenimine Receptors, Cell Surface Transfection - methods Transfection - standards Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!