Sanglifehrin A Acts as a Potent Inhibitor of the Mitochondrial Permeability Transition and Reperfusion Injury of the Heart by Binding to Cyclophilin-D at a Different Site from Cyclosporin A

Cyclosporin A (CsA) inhibits opening of the mitochondrial permeability transition pore (MPTP), a critical event in some forms of necrotic and apoptotic cell death, by binding to cyclophilin D (CyP-D) and inhibiting its peptidyl-prolyl cis-trans isomerase (PPIase) activity. Sanglifehrin A (SfA), like...

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Veröffentlicht in:	The Journal of biological chemistry 2002-09, Vol.277 (38), p.34793-34799
Hauptverfasser:	Clarke, Samantha J, McStay, Gavin P, Halestrap, Andrew P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cell Membrane Permeability - drug effects Cyclophilins - metabolism Cyclosporine - metabolism In Vitro Techniques Lactones - pharmacology Mitochondria, Heart - drug effects Myocardial Reperfusion Injury - prevention & control Peptidyl-Prolyl Isomerase F Rats Spiro Compounds - pharmacology
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