Evidence that anandamide-signaling regulates human sperm functions required for fertilization

Ejaculated mammalian sperm require several hours exposure to secretions in female reproductive tracts, or incubation in appropriate culture medium in vitro, before acquiring the capacity to fertilize eggs. Arachidonylethanolamide (AEA), also known as anandamide, is a novel lipid‐signal molecule that...

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Veröffentlicht in:	Molecular reproduction and development 2002-11, Vol.63 (3), p.376-387
Hauptverfasser:	Schuel, Herbert, Burkman, Lani J., Lippes, Jack, Crickard, Kent, Mahony, Mary C., Giuffrida, Andrea, Picone, Robert P., Makriyannis, Alexandros
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome - metabolism Arachidonic Acids - metabolism Biological and medical sciences cannabinoid receptor Cannabinoid Receptor Modulators Cannabinoids - agonists Cannabinoids - pharmacology eicosanoid endocannabinoid Endocannabinoids Fertility - physiology fertilization Fertilization - drug effects Fertilization - physiology follicular fluid Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Male Mammalian male genital system N-acylethanolamides oviductal fluid Polyunsaturated Alkamides Psychotropic Drugs - agonists Psychotropic Drugs - pharmacology Receptors, Cannabinoid Receptors, Drug - metabolism seminal plasma Signal Transduction - drug effects Signal Transduction - physiology sperm capacitation Spermatozoa - drug effects Spermatozoa - metabolism Vertebrates: reproduction
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