Hypolipidemic effects of NB-598 in dogs

NB-598, a new inhibitor of mammalian squalene epoxidase, was found to be a potent inhibitor of microsomal squalene epoxidase from dog liver. Hypolipidemic effects of NB-598 were compared with those of simvastatin (MK-733, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor) in dogs. NB-598 w...

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Veröffentlicht in:	Atherosclerosis 1991-06, Vol.88 (2), p.183-192
Hauptverfasser:	Horie, Masahiro, Sawasaki, Yoshio, Fukuzumi, Hitoshi, Watanabe, Keiko, Iizuka, Yuri, Tsuchiya, Yoshimi, Kamei, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Benzylamines - pharmacology Bile - metabolism Bile acids Bile Acids and Salts - metabolism Biological and medical sciences Cholesterol Cholesterol - blood Cholesterol - metabolism Dog Dogs Ent. Stomatology Feces - chemistry Hypolipidemic drug Lipids - blood Lipoprotein Lipoproteins - blood Lovastatin - analogs & derivatives Lovastatin - pharmacology Male Medical sciences NB-598 Oxygenases - antagonists & inhibitors Pharmacology. Drug treatments Phospholipids - blood Simvastatin Squalene Squalene - blood Squalene - metabolism Squalene epoxidase inhibitor Squalene Monooxygenase Thiophenes - pharmacology Triglycerides - blood
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