Gram-negative sepsis. Background, clinical features, and intervention
Gram-negative sepsis remains an urgent medical problem, with more than 200,000 cases occurring each year in the United States and an associated mortality rate of 20 to 50 percent. Since the onset of shock greatly worsens prognosis and to encourage early intervention, the term sepsis syndrome was dev...
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| Veröffentlicht in: | Chest 1991-09, Vol.100 (3), p.802-808 |
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| creator | BONE, R. C |
| description | Gram-negative sepsis remains an urgent medical problem, with more than 200,000 cases occurring each year in the United States
and an associated mortality rate of 20 to 50 percent. Since the onset of shock greatly worsens prognosis and to encourage
early intervention, the term sepsis syndrome was developed to describe the features of a preshock septic state. Early clinical
and metabolic indicators are discussed, and current therapy is reviewed. Better understanding of the pathophysiology of endotoxin
release from Gram-negative bacteria and advances in biotechnology have led to the development of potential new treatments
for sepsis. One such development--monoclonal antibodies to endotoxin--has shown great promise in the effort to block the progression
to septic shock, reduce mortality, and decrease the overall costs of sepsis to the patient and to the national economy. |
| doi_str_mv | 10.1378/chest.100.3.802 |
| format | Article |
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and an associated mortality rate of 20 to 50 percent. Since the onset of shock greatly worsens prognosis and to encourage
early intervention, the term sepsis syndrome was developed to describe the features of a preshock septic state. Early clinical
and metabolic indicators are discussed, and current therapy is reviewed. Better understanding of the pathophysiology of endotoxin
release from Gram-negative bacteria and advances in biotechnology have led to the development of potential new treatments
for sepsis. One such development--monoclonal antibodies to endotoxin--has shown great promise in the effort to block the progression
to septic shock, reduce mortality, and decrease the overall costs of sepsis to the patient and to the national economy.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.100.3.802</identifier><identifier>PMID: 1889276</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Bacterial diseases ; Bacterial Infections - diagnosis ; Bacterial Infections - physiopathology ; Bacterial Infections - therapy ; Biological and medical sciences ; Gram-Negative Bacteria ; Humans ; Infectious diseases ; Medical sciences ; Shock, Septic - etiology ; Shock, Septic - physiopathology</subject><ispartof>Chest, 1991-09, Vol.100 (3), p.802-808</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5417268$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1889276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BONE, R. C</creatorcontrib><title>Gram-negative sepsis. Background, clinical features, and intervention</title><title>Chest</title><addtitle>Chest</addtitle><description>Gram-negative sepsis remains an urgent medical problem, with more than 200,000 cases occurring each year in the United States
and an associated mortality rate of 20 to 50 percent. Since the onset of shock greatly worsens prognosis and to encourage
early intervention, the term sepsis syndrome was developed to describe the features of a preshock septic state. Early clinical
and metabolic indicators are discussed, and current therapy is reviewed. Better understanding of the pathophysiology of endotoxin
release from Gram-negative bacteria and advances in biotechnology have led to the development of potential new treatments
for sepsis. One such development--monoclonal antibodies to endotoxin--has shown great promise in the effort to block the progression
to septic shock, reduce mortality, and decrease the overall costs of sepsis to the patient and to the national economy.</description><subject>Bacterial diseases</subject><subject>Bacterial Infections - diagnosis</subject><subject>Bacterial Infections - physiopathology</subject><subject>Bacterial Infections - therapy</subject><subject>Biological and medical sciences</subject><subject>Gram-Negative Bacteria</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Shock, Septic - etiology</subject><subject>Shock, Septic - physiopathology</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMoOj7WroQuxJWteTWPpYovENzouqTpzUy0TcekHfHfG3RwdbmcjwPfQeiU4Iowqa7sCtJUEYwrVilMd9CCaEZKVnO2ixYYE1oyoekBOkzpHeefaLGP9olSmkqxQHcP0QxlgKWZ_AaKBOvkU1XcGPuxjOMcusvC9j54a_rCgZnmCOmyMKErfJggbiBMfgzHaM-ZPsHJ9h6ht_u719vH8vnl4en2-rlcUVlPJRfccCOldgIU123bga5rkKoFoZy2LeaCGNc5R62ErgbaEW2pU4wrR2vKjtDFX-86jp9zNm8Gnyz0vQkwzqmRFGtKuMjg2Rac2wG6Zh39YOJ3s_XO-fk2NymruWiC9ekfqzmRVKiMXf1hK79cffkITRpM3-dS1vwu_z7OMZg-79-wJu_PfgDN5niL</recordid><startdate>19910901</startdate><enddate>19910901</enddate><creator>BONE, R. C</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19910901</creationdate><title>Gram-negative sepsis. Background, clinical features, and intervention</title><author>BONE, R. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h275t-464a4a779f6e849bbde955e78be68f9cb0461afdff2c7ed5e2d19c2f8348f2523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Bacterial diseases</topic><topic>Bacterial Infections - diagnosis</topic><topic>Bacterial Infections - physiopathology</topic><topic>Bacterial Infections - therapy</topic><topic>Biological and medical sciences</topic><topic>Gram-Negative Bacteria</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Shock, Septic - etiology</topic><topic>Shock, Septic - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BONE, R. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BONE, R. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gram-negative sepsis. Background, clinical features, and intervention</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1991-09-01</date><risdate>1991</risdate><volume>100</volume><issue>3</issue><spage>802</spage><epage>808</epage><pages>802-808</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Gram-negative sepsis remains an urgent medical problem, with more than 200,000 cases occurring each year in the United States
and an associated mortality rate of 20 to 50 percent. Since the onset of shock greatly worsens prognosis and to encourage
early intervention, the term sepsis syndrome was developed to describe the features of a preshock septic state. Early clinical
and metabolic indicators are discussed, and current therapy is reviewed. Better understanding of the pathophysiology of endotoxin
release from Gram-negative bacteria and advances in biotechnology have led to the development of potential new treatments
for sepsis. One such development--monoclonal antibodies to endotoxin--has shown great promise in the effort to block the progression
to septic shock, reduce mortality, and decrease the overall costs of sepsis to the patient and to the national economy.</abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>1889276</pmid><doi>10.1378/chest.100.3.802</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Chest, 1991-09, Vol.100 (3), p.802-808 |
| issn | 0012-3692 1931-3543 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Bacterial diseases Bacterial Infections - diagnosis Bacterial Infections - physiopathology Bacterial Infections - therapy Biological and medical sciences Gram-Negative Bacteria Humans Infectious diseases Medical sciences Shock, Septic - etiology Shock, Septic - physiopathology |
| title | Gram-negative sepsis. Background, clinical features, and intervention |
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