Desmosomal cadherins
New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mi...
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| Veröffentlicht in: | Current Opinion in Cell Biology 2002-10, Vol.14 (5), p.537-545 |
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| container_title | Current Opinion in Cell Biology |
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| creator | Garrod, David R Merritt, Anita J Nie, Zhuxiang |
| description | New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.
New evidence suggests that desmosomal adhesion may have a role in regulating epidermal differentiation and cell positioning in morphogenesis, in addition to its traditional role in cell-cell adhesion. |
| doi_str_mv | 10.1016/S0955-0674(02)00366-6 |
| format | Article |
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New evidence suggests that desmosomal adhesion may have a role in regulating epidermal differentiation and cell positioning in morphogenesis, in addition to its traditional role in cell-cell adhesion.</description><subject>Animals</subject><subject>cadherin</subject><subject>Cadherins - chemistry</subject><subject>Cell Adhesion</subject><subject>desmocollin</subject><subject>desmoglein</subject><subject>desmoplakin</subject><subject>desmosome</subject><subject>Desmosomes - metabolism</subject><subject>Epidermis - metabolism</subject><subject>Genotype</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Models, Biological</subject><subject>Phenotype</subject><subject>plakoglobin</subject><subject>plakophilin</subject><subject>Protein Binding</subject><issn>0955-0674</issn><issn>1879-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqWwsYKYEAyBOzu2e1OFyqdUiQGYrcS-iqCkKXaLxL8n_RCMTLc87716XiFOEK4Q0Fy_AGmdgbH5BchLAGVMZnZEH4eWMsgRdkX_F-mJg5Q-AMCApH3RQykVqtz2xfEtp6ZNbVPUZ74I7xyrWToUe9OiTny0vQPxdn_3On7MJs8PT-ObSeaVwUWmAktPqBBCMKiZIGhLFPyQiKwtjCc51VQaxLwoQXuWusxD0LL0WlOuBuJ883ce288lp4VrquS5rosZt8vkrIShQaIO1BvQxzalyFM3j1VTxG-H4FZzuPUcbuXqQLr1HM50udNtwbJsOPyltv4dMNoA3Gl-VRxd8hXPPIcqsl-40Fb_VPwASvNsuA</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Garrod, David R</creator><creator>Merritt, Anita J</creator><creator>Nie, Zhuxiang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Desmosomal cadherins</title><author>Garrod, David R ; Merritt, Anita J ; Nie, Zhuxiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-3de2c91310dd615e90d5799dc899977a6c92f59b6114ab05ce25b4dd52bc55943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>cadherin</topic><topic>Cadherins - chemistry</topic><topic>Cell Adhesion</topic><topic>desmocollin</topic><topic>desmoglein</topic><topic>desmoplakin</topic><topic>desmosome</topic><topic>Desmosomes - metabolism</topic><topic>Epidermis - metabolism</topic><topic>Genotype</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Models, Biological</topic><topic>Phenotype</topic><topic>plakoglobin</topic><topic>plakophilin</topic><topic>Protein Binding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garrod, David R</creatorcontrib><creatorcontrib>Merritt, Anita J</creatorcontrib><creatorcontrib>Nie, Zhuxiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current Opinion in Cell Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garrod, David R</au><au>Merritt, Anita J</au><au>Nie, Zhuxiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Desmosomal cadherins</atitle><jtitle>Current Opinion in Cell Biology</jtitle><addtitle>Curr Opin Cell Biol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>14</volume><issue>5</issue><spage>537</spage><epage>545</epage><pages>537-545</pages><issn>0955-0674</issn><eissn>1879-0410</eissn><abstract>New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.
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| ispartof | Current Opinion in Cell Biology, 2002-10, Vol.14 (5), p.537-545 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals cadherin Cadherins - chemistry Cell Adhesion desmocollin desmoglein desmoplakin desmosome Desmosomes - metabolism Epidermis - metabolism Genotype Humans Mice Mice, Knockout Models, Biological Phenotype plakoglobin plakophilin Protein Binding |
| title | Desmosomal cadherins |
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