The Backbone Conformational Entropy of Protein Folding: Experimental Measures from Atomic Force Microscopy

The energy dissipated during the atomic force microscopy-based mechanical unfolding and extension of proteins is typically an order of magnitude greater than their folding free energy. The vast majority of the “excess” energy dissipated is thought to arise due to backbone conformational entropy loss...

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Veröffentlicht in:	Journal of molecular biology 2002-09, Vol.322 (3), p.645-652
Hauptverfasser:	Thompson, James B., Hansma, Helen G., Hansma, Paul K., Plaxco, Kevin W.
Format:	Artikel
Sprache:	eng
Schlagworte:	configurational entropy Entropy Microscopy, Atomic Force Protein Binding Protein Conformation Protein Denaturation Protein Folding Thermodynamics worm-like chain
Online-Zugang:	Volltext
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