The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines

The trk tyrosine kinase proto-oncogene product gp140 prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140 prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high af...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 1991-09, Vol.66 (5), p.961-966
Hauptverfasser:	Loeb, David M., Maragos, Johnna, Martin-Zanca, Dionisio, Chao, Moses V., Parada, Luis F., Greene, Lloyd A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - genetics Adrenal Gland Neoplasms - pathology Animals Biological and medical sciences Blotting, Northern Carbazoles - pharmacology Cell Differentiation Cell Division Cell physiology Cell Survival Fundamental and applied biological sciences. Psychology Gene Expression In Vitro Techniques Indole Alkaloids Molecular and cellular biology Nerve Growth Factors - physiology Pheochromocytoma - physiopathology Protein Kinase Inhibitors Protein-Tyrosine Kinases - physiology Proto-Oncogene Proteins - genetics Rats Receptor, trkA Receptors, Cell Surface - physiology Receptors, Nerve Growth Factor RNA, Messenger - genetics Signal Transduction Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!