The Active Site of a Zinc-Dependent Metalloproteinase Influences the Computed pK a of Ligands Coordinated to the Catalytic Zinc Ion

TNF-α converting enzyme (TACE) is a multidomain, membrane-anchored protein that includes a Zn-dependent protease domain. It releases the soluble form of cytokine tumor necrosis factor-α (TNF-α) from its membrane-bound precursor. TACE is a metalloprotease containing a catalytic glutamic acid, Glu-406...

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