The effects of intravenous clonidine on ventilation
Summary The effects of clonidine, an alpha 2 adrenergic agonist, on ventilation were studied in a group of adult volunteers. The ventilatory variables measured were minute ventilation, respiratory rate, end‐tidal carbon dioxide tension and the response to carbon dioxide challenge. We found no differ...
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| Veröffentlicht in: | Anaesthesia 1991-08, Vol.46 (8), p.632-633 |
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| container_title | Anaesthesia |
| container_volume | 46 |
| creator | OOI, R. PATTISON, J. FELDMAN, S. A. |
| description | Summary
The effects of clonidine, an alpha 2 adrenergic agonist, on ventilation were studied in a group of adult volunteers. The ventilatory variables measured were minute ventilation, respiratory rate, end‐tidal carbon dioxide tension and the response to carbon dioxide challenge. We found no differences in minute ventilation, respiratory rate and end‐tidal carbon dioxide tension, before and after clonidine administration. However, the ventilatory response to carbon dioxide was significantly attenuated following clonidine, suggesting that clonidine has respiratory depressant effects. |
| doi_str_mv | 10.1111/j.1365-2044.1991.tb09709.x |
| format | Article |
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The effects of clonidine, an alpha 2 adrenergic agonist, on ventilation were studied in a group of adult volunteers. The ventilatory variables measured were minute ventilation, respiratory rate, end‐tidal carbon dioxide tension and the response to carbon dioxide challenge. We found no differences in minute ventilation, respiratory rate and end‐tidal carbon dioxide tension, before and after clonidine administration. However, the ventilatory response to carbon dioxide was significantly attenuated following clonidine, suggesting that clonidine has respiratory depressant effects.</description><identifier>ISSN: 0003-2409</identifier><identifier>EISSN: 1365-2044</identifier><identifier>DOI: 10.1111/j.1365-2044.1991.tb09709.x</identifier><identifier>PMID: 1909506</identifier><identifier>CODEN: ANASAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Pressure - drug effects ; Carbon Dioxide ; Catecholaminergic system ; clonidine ; Clonidine - administration & dosage ; Clonidine - pharmacology ; Depression, Chemical ; Drug Evaluation ; Female ; Heart Rate - drug effects ; Humans ; Injections, Intravenous ; Male ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology ; Pharmacology. Drug treatments ; Respiration - drug effects ; Ventilation</subject><ispartof>Anaesthesia, 1991-08, Vol.46 (8), p.632-633</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4512-85262175509ea26159ccc0e03ca970758ff41188da8a562060a9de394eab57353</citedby><cites>FETCH-LOGICAL-c4512-85262175509ea26159ccc0e03ca970758ff41188da8a562060a9de394eab57353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2044.1991.tb09709.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2044.1991.tb09709.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5598276$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1909506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OOI, R.</creatorcontrib><creatorcontrib>PATTISON, J.</creatorcontrib><creatorcontrib>FELDMAN, S. A.</creatorcontrib><title>The effects of intravenous clonidine on ventilation</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>Summary
The effects of clonidine, an alpha 2 adrenergic agonist, on ventilation were studied in a group of adult volunteers. The ventilatory variables measured were minute ventilation, respiratory rate, end‐tidal carbon dioxide tension and the response to carbon dioxide challenge. We found no differences in minute ventilation, respiratory rate and end‐tidal carbon dioxide tension, before and after clonidine administration. However, the ventilatory response to carbon dioxide was significantly attenuated following clonidine, suggesting that clonidine has respiratory depressant effects.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Carbon Dioxide</subject><subject>Catecholaminergic system</subject><subject>clonidine</subject><subject>Clonidine - administration & dosage</subject><subject>Clonidine - pharmacology</subject><subject>Depression, Chemical</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiration - drug effects</subject><subject>Ventilation</subject><issn>0003-2409</issn><issn>1365-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1LwzAUhoMoc05_glBEvGs9SZo28UbGmB8w9GZehyxNMKNLZ9Pp9u9taZnX5iaQ9zk5Lw9CNxgS3J77dYJpxmICaZpgIXDSrEDkIJL9CRofo1M0BgAakxTEOboIYQ2ACcd8hEZYgGCQjRFdfprIWGt0E6LKRs43tfo2vtqFSJeVd4XzJqp81L41rlSNq_wlOrOqDOZquCfo42m-nL3Ei_fn19l0EeuUYRJzRjKCc8ZAGEUyzITWGgxQrdqyOePWphhzXiiuWEYgAyUKQ0Vq1IrllNEJuuv_3dbV186ERm5c0KYslTdtP5kT4DjltAUfelDXVQi1sXJbu42qDxKD7IzJtey0yE6L7IzJwZjct8PXw5bdamOKv9FeUZvfDrkKWpW2Vl67cMQYE5zkHfbYYz-uNId_FJDTt-k8o4T-AhVWhoU</recordid><startdate>199108</startdate><enddate>199108</enddate><creator>OOI, R.</creator><creator>PATTISON, J.</creator><creator>FELDMAN, S. A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199108</creationdate><title>The effects of intravenous clonidine on ventilation</title><author>OOI, R. ; PATTISON, J. ; FELDMAN, S. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4512-85262175509ea26159ccc0e03ca970758ff41188da8a562060a9de394eab57353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Carbon Dioxide</topic><topic>Catecholaminergic system</topic><topic>clonidine</topic><topic>Clonidine - administration & dosage</topic><topic>Clonidine - pharmacology</topic><topic>Depression, Chemical</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Respiration - drug effects</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OOI, R.</creatorcontrib><creatorcontrib>PATTISON, J.</creatorcontrib><creatorcontrib>FELDMAN, S. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OOI, R.</au><au>PATTISON, J.</au><au>FELDMAN, S. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of intravenous clonidine on ventilation</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>1991-08</date><risdate>1991</risdate><volume>46</volume><issue>8</issue><spage>632</spage><epage>633</epage><pages>632-633</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>Summary
The effects of clonidine, an alpha 2 adrenergic agonist, on ventilation were studied in a group of adult volunteers. The ventilatory variables measured were minute ventilation, respiratory rate, end‐tidal carbon dioxide tension and the response to carbon dioxide challenge. We found no differences in minute ventilation, respiratory rate and end‐tidal carbon dioxide tension, before and after clonidine administration. However, the ventilatory response to carbon dioxide was significantly attenuated following clonidine, suggesting that clonidine has respiratory depressant effects.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1909506</pmid><doi>10.1111/j.1365-2044.1991.tb09709.x</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anaesthesia, 1991-08, Vol.46 (8), p.632-633 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Blood Pressure - drug effects Carbon Dioxide Catecholaminergic system clonidine Clonidine - administration & dosage Clonidine - pharmacology Depression, Chemical Drug Evaluation Female Heart Rate - drug effects Humans Injections, Intravenous Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology Pharmacology. Drug treatments Respiration - drug effects Ventilation |
| title | The effects of intravenous clonidine on ventilation |
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