Control of complex formation of DNA polymerase α–primase and cell‐free DNA replication by the C‐terminal amino acids of the largest subunit p180

DNA polymerase α–primase is a heterotetrameric complex essential for simian vacuolating virus 40 (SV40) DNA replication. We show that the C‐terminal 67 amino acid residues of the human p180 subunit are essential for SV40 DNA replication as they are required for binding of the p68 subunit and play a...

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Veröffentlicht in:	FEBS letters 2002-09, Vol.527 (1-3), p.143-146
Hauptverfasser:	Smith, R.W.P, Nasheuer, H.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell-Free System DNA Polymerase I - genetics DNA Polymerase I - metabolism DNA polymerase α DNA Primase - genetics DNA Primase - metabolism DNA Replication Enzyme activity Humans Mice Protein Subunits Protein–protein interaction Sequence Deletion Simian vacuolating virus 40 DNA replication Simian virus 40 - genetics SV40, simian vacuolating virus 40 TAg, large T antigen
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